Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2002-12-18
2008-08-05
Saidha, Tekchand (Department: 1652)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C424S094400, C424S094500
Reexamination Certificate
active
07407986
ABSTRACT:
The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracellular levels of at least one Phase II detoxification enzyme in animal tissue. The present invention also relates to the field of protecting a subject from oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracellular levels of at least one Phase II detoxification enzyme in the subject. The present invention also relates to a pharmaceutical composition useful for the treatment of oxidative stress disorders.
REFERENCES:
patent: 5411986 (1995-05-01), Cho et al.
patent: 5747459 (1998-05-01), Rowe et al.
patent: RE36784 (2000-07-01), Cho et al.
patent: 6159500 (2000-12-01), Demopoulos et al.
patent: 6495170 (2002-12-01), Smit et al.
patent: 1469711 (2004-01-01), None
patent: 0 655 245 (1995-05-01), None
patent: WO 01/45661 (2001-06-01), None
patent: WO 02/15722 (2002-02-01), None
Prochaska, et al., Oxidative Stress: Oxidants and Antioxidants, 195-211 (1991).
Favreau, et al., J. Biol. Chem. 266:4556-4561 (1991).
Wally et al. [Food and Chemical Toxicology 36 (1998): 365-373].
Gao et al., “Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane,”Proceedings of the National Academy of Sciences of the United States of America, vol. 98, No. 26, Dec. 18, 2001, p. 15221, XP002392650.
Harman, “Free radical theory of ageing: Applications,”The Asia Pacific Heart Journal, vol. 7, No. 3, Dec. 1998, pp. 169-177, XP004886293.
Jakoby et al., “The enzymes of detoxication,”The Journal of Biological Chemistry, vol. 265, No. 34, 1990, pp. 20715-20718, XP002392651.
Fahey et al., “Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protect Against Chemical Carcinogens,”Proc. Natl. Acad. Sci., vol. 94, Sep. 16, 1997, USA, pp. 10367-10372.
Fahey et al., “Antioxidant Functions of Sulforaphane: a Potent Inducer of Phase II Detoxication Enzymes,”Food and Chemical Toxicology, vol. 37, Elsevier Science Ltd., GB, 1999, pp. 973-979.
Fahey et al., “The Chemical Diversity and Distribution of Glucosinolates and Isothiocyanates Among Plants,”Photochemistry, vol. 56, Elsevier Science Ltd., 2000, pp. 5-51.
Mulcahy et al., “Constitutive and B-Naphthoflavone-induced Expression of the Human Y-Glutamylcysteine Synthetase Heavy Subunit Gene Is Regulated by a Distal Antioxidant Response Element/TRE Sequence,”J. Biol. Chem., vol. 272, Mar. 14, 1997, pp. 7445-7454.
Thimmulappa et al., “Identification of Nrf2-regulated Genes Induced by the Cemopreventive agent Sulforaphane by Oligonucleotide Microarray,”Cancer Research, vol. 62, Sep. 15, 2002, pp. 5196-5203.
Zhang et al., “A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure,”Proc. Natl. Acad. Sci., vol. 89, USA, Mar. 15, 1992, pp. 2399-2403.
Zhang et al., “Anticarcinogenic Activities of Sulforaphane and Structurally Related Synthetic Norbornyl Isothiocyanates,”Proc. Natl. Acad. Sci., vol. 91, USA, Apr. 12, 1994, pp. 3147-3150.
Smith et al., “Effects of the Antioxidant Butylated Hydroxytoluene (BHT) on Retinal Degenration Induced Transplacentally by a Single Low Dosage of N-Methyl-N-Nitrosourea (MNU)”, Teratogenesis, Carcinogenesis, and Mutagenesis 8:175-189 (1988).
Verna et al., “UVA-induced oxidative damage in retinal pigment epithelial cells after H2O2or sparfloxacin exposure”, Cell Biology and Toxicology, 2000:16, pp. 303-312.
Nelson et al., Effect of Dietary Inducer Dimethylfumarate on Glutathione in Cultured Human Retinal Pigment Epithelial Cells, Investigative Ophhthalmology & Visual Science, Aug. 1999, vol. 40, No. 9, pp. 1927-1935.
Winkler et al., “Oxidative damage and age-related macular degeneration”, Molecular Vision 1999; 5:31, pp. 1-11.
Cai et al., “Oxidative Damage and Protection of the RPE”, Progress in Retinal and Eye Research, vol. 19, No. 2, (2000) pp. 205-221.
In re Cruciferous Sprout Litigation 301 F.3d 1343 (Fed.Cir. 2002).
Dinkova-Kostova Albena T.
Gao Xiangqun
Talalay Paul
Brassica Foundation for Chemoprotection Research, Inc.
Foley & Lardner LLP
Saidha Tekchand
LandOfFree
Prevention and treatment of oxidative stress disorders by... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Prevention and treatment of oxidative stress disorders by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prevention and treatment of oxidative stress disorders by... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3995931