Prevention and treatment of occlusive cardiovascular disease wit

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514356, 514474, 514824, A61K 31195, A61K 3134, A61K 3144

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active

052781895

ABSTRACT:
A method is provided for prevention and treatment of cardiovascular disease, such as atherosclerosis, by administering therapeutically effective dosages of a drug comprised of ascorbate, lipoprotein(a) binding inhibitors, and antioxidants.

REFERENCES:
patent: 3956504 (1976-05-01), Sawyer
patent: 4424232 (1984-01-01), Parkinson
patent: 4600582 (1986-07-01), Stevens et al.
patent: 4954521 (1990-09-01), Sawyer et al.
Chemical Abstracts 77(13):86318 (1972).
Vitamin C in Health and Disease, Basu et al., AVI Publishing Co., Inc. (1982) pp. 95-101.
Martindale, The Extra Pharmacopoeia, 28th edition (1982) p. 56, "Lysine Hydrochloride".
The Nutrition Desk Reference, Garrison et al, Keats Publishing Inc. (1985) pp. 172-177.
Rath, M. & L. Pauling, "Solution of the puzzle of human cardiovascular disease: Its primary cause is ascorbate deficinecy leading to the deposition of lipoprotein(a) and fibrinogen/fibrin in the vascular wall," J. Orthomolecular Med. (In Press 1991).
Markwardt, F. & H. P. Klocking, "Chemical control of hyperfibrinolytic states by synthetic inhibitors of fibrinolytic enzymes," Biomed. Biochim. Acta 42:725-730 (1983).
Werb, Z. et al., "Endogenous activation of latent collagenase by rheumatoid synovial cells," New England J. Med. 296(18):1017-1023 (1977).
Knox, E. G., "Ischaemic-heart-disease mortality and dietary intake of calcium," Lancet, i, pp. 1465-1467, Jun. 30, 1973.
Berg, K. "A new serum type system in man--The LP system," Acta Path. 59:369-382 (1963).
McLean, J. et al., "cDNA sequence of human apolipoprotein(a) is homologous to plasminogen," Nature 300:132-137 (1987).
Salonen, E-M, et al., "Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it," EMBO J. 8(13):4035-4040 (1989.
Harpel, P.C. et al., "Plasmin catalyzes binding of lipoprotein(a) to immobilized fibrinogen and fibrin," Proc. Natl. Acad. Sci. USA 86:3847-3851 (1989).
Gonzalez-Gronow, M. et al., "Further characterization of the cellular plasminogen biding site: Evidence that Plasminogen 2 and Lipoprotein a compete for the same site," Biochemistry 28:2374-2377 (1989).
Hajjar, K. A. et al., "Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis," Nature 339:303-305 (1989).
Armstrong, V. W. et al., "The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosis"; Atheroscloerosis 62:249-257 (1986).
Dahlen, G. H. et al., "Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography," Circulation 74(4): 758-765 (1986).
Miles, L. A. et al., "A potential basis for the thrombotic risks associated with Lipoprotein (a)," Nature 339:301-302 (1989).
Zenker, G. et al., "Lipoprotein(a) as a strong indicator for cerebrovascular disease," Stroke 17(5)942-945 (1986).
Zechner, R. et al., "Fluctuations of plasma Lipoprotein-A concentrations during pregnancy and post partum," Metabolism 35(4):333-336 (1986).
Hoff, H. et al., "Serum Lp(a) level as a predictor of vein graft stenosis after coronary artery bypass surgery in patients," Circulation 77(6):1238-1244 (1988).
Rath, M. et al., "Detection and quantification of Lipoprotein(a) in the arterial wall of 107 coronary bypass patients," Arteriosclerosis 9(5):579-592 (1989).
Cushing, G. L. et al., "Quantitation and localization of Apolipoproteins [a] and B in Coronary artery bypass vein grafts resected at re-operation," Arteriosclerosis 9(5):593-603 (1989).
Bruckert, E. et al., "Increased serum levels of Lipoprotein(a) in diabetes mellitus and their reduction with glycemic control," JAMA 263(1):35-36 (1990).
Blumberg, B., et al., "A human lipoprotein polymorphism," J. Clin. Invest. 41:1936-1944 (1962).
Eaton, D. L., et al., "Partial amoni acid sequence of apolipoprotein(a) shows that it is homologous to plasminogen," Proc. Natl. Acad. Sci. USA, 84:3224-3228 (1987).
Wright, L. C. et al., "Elevated apolipoprotein(a) levels in cancer patients," Int. J. Cancer 43:241-244 (1989).
Som, S. et al., "Ascorbic acid metabolism in diabetes mellitus," Metabolism 30:572-577 (1981).
Maeda, S. et al., "Transient changes in serum lipoprotein(a) as an acute phase protein," Atherosclerosis 78:145-150 (1989).
Kapeghian, J. C. et al., "The effects of glucose on ascorbic acid uptake in heart, endothelial cells: Possible pathogenesis of diabetic angiopathies," Life Sci. 34:577 (1984).
Tomlinson, J. E. et al., "Rhesus monkey apolipoprotein(a)," J. Biol. Chem. 264:5957-5965 (1989).
Ginter, E. et al., "The effect of chronic hypovitaminosis C on the metabolism of cholesterol and athergenesis in guinea pigs," J. Atherosclerosis Res. 10:341-352 (1969).

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