Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1996-01-17
1997-12-23
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
A61K 3159
Patent
active
057007900
ABSTRACT:
Method of increasing the strength of contraction in the mammalian heart muscle by administering to the mammal an effective amount of an activated Vitamin D compound, i.e. a 1.alpha.-hydroxylated Vitamin D compound which binds with the Vitamin D receptor and produces a positive inotropic effect in the heart muscle. The activated Vitamin D compound may be given as a means to prevent myocardial failure or to treat myocardial failure.
REFERENCES:
patent: 4501737 (1985-02-01), Yamato et al.
R.J.S. McGonigle, Nephron, vol. 36, No. 2, 1984, pp. 94-100.
A.R.J. Bosley, Arch. Dis. Child., vol. 55, No. 9, 1980, pp. 683-686.
A.M. Feldman, M.D., Am. J. Kidney Dis., vol. 11, No. 1, 1988, pp. 76-79.
G.M. Diffee, Biophys. J., vol. 64, No. 2, Feb. 14, 1993, p. A254, abstract No. W-Pos-30.
M. R. Walters et al., "1,25-Dihydroxyvitamin D.sub.3 Receptors Identified in the Rat Hear.," J. Mol. Cell. Cardiol., 1986; 18 pp. 67-72.
R. E. Weishaar and R. U. Simpson, "Vitamin D.sub.3 and Cardiovascular Function in Rats," J. Clin. Invest., 1987; 79 pp. 1706-1712.
R. E. Weishaar and R. U. Simpson, "Involvement of Vitamin D.sub.3 with Cardiovascular Function II. Direct and Indirect Effects," Am. J. Physiol., 1987; 253 (Endocrinol Metab 16) pp. E675-E683.
J. Sellers and R. Boland, "Rapid Stimulation of Calcium Uptake and Protein Phosphorylation in Isolated Cardiac Muscle by 1,25-dihydroxyvitamin D.sub.3 ," Mol. and Cell. Endocrinol., 1991; 77 pp. 67-73.
Weishaar et al., Chemical Abstracts, vol. 112 (15), No. 133090g, 1990.
Gulbrandsen Carl E.
Moss Richard L.
Bone Care International, Inc.
Jarvis William R. A.
Welch Teresa J.
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