Prevention and treatment of ischemic events and reperfusion inju

Details Prevention and treatment of ischemic events and reperfusion inju Prevention and treatment of ischemic events and reperfusion inju

1994-06-08

1996-05-28

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

514 2, 514 12, 514802, A61K 3848, A01N 3718

Patent

active

055209122

ABSTRACT:
A treatment of ischemia and the attendant reperfusion injury entails the administration plasmin and plasmin-forming proteins, including lys-plasminogen and similar substances. Lys-plasminogen, which can be obtained from the proteolytic cleavage of glu-plasminogen, has been found to have a protective effect on tissue that has been injured by ischemic conditions. The administration of lys-plasminogen can used to treat subjects during the time of reperfusion and after reperfusion has already occurred. Lys-plasminogen also can be administered in conjunction with clot lysis therapies, such as those that employ tissue plasminogen activator and the like.

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