Prevention and treatment of amyloidogenic disease

Details Prevention and treatment of amyloidogenic disease Prevention and treatment of amyloidogenic disease

2007-08-20

2011-10-11

Kolker, Daniel E (Department: 1649)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S192100, C424S193100, C424S197110, C424S238100, C514S017800, C514S021600, C514S021700

Reexamination Certificate

active

08034348

ABSTRACT:
The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer's disease. Preferred agents including N-terminal fragments of Aβ and antibodies binding to the same.

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