Prevention and improvement of allergy caused by leucotriene B 4

Details Prevention and improvement of allergy caused by leucotriene B 4 Prevention and improvement of allergy caused by leucotriene B 4

1996-07-29

1998-11-10

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

A61K 3120

Patent

active

058345124

ABSTRACT:
A composition such as foods, drinks, pharmaceutical composition, for prevention or improvement of allergy, comprising an omega 9 series unsaturated fatty acid such as 6,9-octadecadienoic acid, 8,11-eicosadienoic acid, 5,8,11-eicosatrienoic acid etc.

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Nguyen et al, "New Model of a Scaling Dermatosis: Induction of Hyperproliferation in Hairless Mice with Eicosa-5,8,11-Trienoic Acid", J. Invest. Dermatol., vol. 76(5), pp. 384-387, (1981).
Stenson et al, "Leukotriene B Formation By Neutrophils From Essential Fatty Acid-deficient Rats", J. Bio. Chem., vol. 259(19), pp. 11784-11789 (1984).
Adkisson et al, "Unique Fatty Acid Composition of Normal Cartilage: Discovery of High Levels of n-9 Eicosatrienoic Acid and Low Levels of n-6 Polyunsaturated Fatty Acids", Faseb J., vol. 5(3), pp. 344-353 (1991).
James et al, Effect of Dietary Supplementation with N-9 Cicosatrienoic Acid on Keukotriene B4 Synthesis in Rats: A Novel Approach to Inhibition of Eicosanoid Synthesis, J. Exp. Med., vol. 178(6), pp. 2261-2265 (1993).
Jakschik et al, "Products Derived from 5,8,11-Eicosatrienoic Acid by the 5-Lipoxygenase-Leukotriene Pathway," J. Bio. Chem., pp. 12797-12800 (1983).
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