Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds bacterium or component thereof or substance produced...
Reexamination Certificate
2006-08-08
2006-08-08
Smith, Lynette R. F. (Department: 1645)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds bacterium or component thereof or substance produced...
C536S023700, C530S388400
Reexamination Certificate
active
07087228
ABSTRACT:
The present invention provides compositions, medicaments, and methods for the treatment or prophylaxis of conditions associated with the binding ofStreptococcus mutansto teeth. Specifically, the present invention provides a method for preventing dental caries and infective endocarditis in a subject by treating the subject's oral cavity with a composition or medicament comprising the competence stimulating peptide (CSP) of the causative bacterium, which inhibits the ability of the said bacteria to attach to the surface of teeth. Novel anti-caries compositions using the CSP are also disclosed.
REFERENCES:
patent: 4692407 (1987-09-01), Jordan et al.
patent: 4725576 (1988-02-01), Pollock et al.
patent: 5013542 (1991-05-01), Hay et al.
patent: 5374538 (1994-12-01), Bratthall
patent: 5486503 (1996-01-01), Oppenheim et al.
patent: 5631228 (1997-05-01), Oppenheim et al.
patent: 5646119 (1997-07-01), Oppenheim et al.
patent: 5801226 (1998-09-01), Cummins et al.
patent: 5807541 (1998-09-01), Aberg et al.
patent: 5830489 (1998-11-01), Valenti et al.
patent: 5885965 (1999-03-01), Oppenheim et al.
patent: 5912230 (1999-06-01), Oppenheim et al.
patent: 6136298 (2000-10-01), Gaffar et al.
patent: 6231857 (2001-05-01), Shi et al.
patent: 2002/0081302 (2002-06-01), Cvitkovitch et al.
Ooshima, T. et al, Cariostatic activity of cacao mass extract, Archives of oral biology, Sep. 2000, 45(9) p. 805-8.
Kuramitsu, H. et al, Immunological relationships between glucosyltransferase from streptococcus mutans serotypes, Infection and Immunity, Sep. 1976, 14(3), p. 636-44.
Thomas E. Creighton, in his book, “Proteins: Structures and Molecular Properties, 1984”, (pp. 314-315).
Thomas E. Creighton, in his book Protein Structure: A Practical Approach, 1989; pp. 184-186.
Nosoh, Y. et al in “Protein Stability and Stabilization through Protein Engineering, 1991” (chapter 7, p. 197, second paragraph).
Kumar, V. et al (Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties: T-cells activation . . . , Immunology, 1990; 87: 1337-1341).
Zero, Sugars- The arch Criminal!, Caries Research, 2004; 38: 277-285.
Idone et al (Effect of an orphan response regulator on Streptococcus mutans sucrose-dependent adherence and cariogenesis, Infection and Immunity, 2003; 71(8): 4351-4360).
Clark et al (Influence of salivary components and extracellular polysaccharide synthesis from sucrose on the attachment of streptococcus mutans 6715 to hydroxyapatite surfaces, Infection and Immunity, 1977; 18(2): 514-523).
Keys (Infective Endocarditis, The Cleveland Clinic, 2004; 1-12).
Ellen, R.P., Microbiological Assays for Dental Caries and Peridontal Disease Susceptibility,Oral Sci. Rev. 8:3-23 (1976).
Fukushima, K., Okada, T., Ochiai, K. “Production Characterization and Application of Monoclonal Antibodies which Distinguish Three Glucosyltransferases fromStreptococcus Mutans,” Infection and Immunity61:323-328 (1993).
Goodman, S.D. and Gao Q., “Firefly Luciferase as a Reporter to Study Gene Expression inStreptococcus Mutans,” Plasmid42:154-157 (1999).
Goodman, S.D. and Gao, Q. “Characterization of thegtfBandgtfCpromoters fromStreptococcus MutansGS-5,”Plasmid43:85-98 (2000).
Goodman, et al. “In Vitro Selection of Integration Host Factor Binding Sites,”J. of Bact. 181-2346-3255 (1999).
Hanada, N., Kuramitsu, H.K., “Isolation and Characterization of theStreptococcus Mutans gtfDGene Coding for Primer-Dependent Soluble Glucan Synthesis,”Infection and Immunity, 57:2079-2085 (1989).
Hume, W.R., “Need for Change in Standards of Caries Diagnosis-Perspective Based on the Structure and Behavior of the Carious Lesion,”J. Dent. Educ.57:439-443 (1993).
Igarashi et al., “Direct Detection ofStreptococcus Mutansin Human Dental Plaque by Polymerase Chain Reaction,”Oral Microbiol an Immunol. 11:294-298 (1996).
Lee, M.S. and Morrison, D.A., “Identification of a New Regulator inStreptococcus PneumociaeLinking Quorum Sensing to Competence for Genetic Transformation,”J. of Bact.181:5004-5016 (1999).
Lenander-Lumikari et al., “Saliva and Dental Caries,”Adv. Dent. Res. 14:40-47 (Dec. 2000).
Li, Y-H et al., “Natural Genetic Transformation ofStreptococcus MutansGrowing in Biofilms,”J. of Bac.183:897-908 (2001).
Tanzer, J.M., “Understanding Dental Caries; an Infectious Disease, not a Lesion,”Inter. J. Oral Biol.22:205-214 (1997).
Goodman Steven D.
Kay Olga
Hogan & Hartson LLP
Smith Lynette R. F.
Tongue Lakia J.
University of Southern California
LandOfFree
Preventing tooth decay and infective endocarditis using... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preventing tooth decay and infective endocarditis using..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preventing tooth decay and infective endocarditis using... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3626278