Preventing conversion of citrulline to argininosuccinate to limi

Details Preventing conversion of citrulline to argininosuccinate to limi Preventing conversion of citrulline to argininosuccinate to limi

1996-03-20

1998-03-03

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514561, 514564, 562560, A61K 3170, A61K 31195, C07C24100

Patent

active

057234485

ABSTRACT:
Administration of argininosuccinate synthetase activity reducing agents, e.g., argininosuccinate synthetase induction blocking agents (e.g., antibiotics that bind to DNA sequences present in the upstream regulatory region of the argininosuccinate synthetase gene, such as mithramycin) and argininosuccinate synthetase inhibitors (e.g., L-citrulline antagonists such as methyl citrulline and L-aspartate antagonists such as D-aspartate) is useful to prevent or treat sepsis or cytokine-induced systemic hypotension, is useful in the treatment of sepsis or cytokine-induced systemic hypotension to restore vascular sensitivity to the effects of .alpha..sub.1 -adrenergic agonists, and is useful to suppress an immune response, e.g., in treating inflammation. In one embodiment, certain argininosuccinate synthetase activity reducing agents are used together with arginine antagonists to treat sepsis or cytokine induced hypotension.

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