Preventing CNS toxicity of acivicin when used with four large ne

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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A61K 31195

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active

050876392

ABSTRACT:
A method for the prevention of central nervous system toxicity of acivicin which comprises the concomitant administration of acivicin and an amino acid solution consisting essentially of large neutral amino acids.

REFERENCES:
Peng et al, J. Nutrition, 103:607-17, 1973, "Food Intake Regulation: Amino Acid Toxicity and Changes in Rat Brain and Plasma Amino Acids".
McGovren et al, Proceedings of AACR, vol. 27, p. 1671, Mar. 1986, "Prevention of Acivicin-Induced CNS Toxicity by Concomitant Amino Acid Infusion".

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