Preventing ADP-ribosylation of G-proteins in a living subject

Details Preventing ADP-ribosylation of G-proteins in a living subject Preventing ADP-ribosylation of G-proteins in a living subject

1988-03-28

1989-11-21

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

514262, 514355, 514562, A61K 3152, A61K 3144, A61K 31195

Patent

active

048821462

ABSTRACT:
Nicotinamide and its analogues (but not nicotinic acid) are effective in preventing or reversing the effects of microbial toxins, e.g. pertussis toxin, which ADP-ribosylate G-proteins.

REFERENCES:
patent: 2283817 (1942-05-01), Martin et al.
patent: 4308257 (1981-12-01), Caspe
Review of Medical Microbiology Jawetz et al., 11th edition, 1974, pp. 136-137.
Carroll et al.; Proceedings in Life Sciences; 1985, pp. 544-550; "ADP Ribosylation of Proteins".
Montanaro et al.; Arch. Sca. Boil., vol. 15, pp. 159-166; 1968; "Effect of Adenine and Nicotinamide on Amino Acid Incorporation of Cell-Free Systems . . . ".
Montanaro et al.; Biochem J., vol. 105, No. 2, pp. 635-640, 1967; "Binding of Nicotinamide-Adenine Dinucleotides to Diphtheria Toxin".
Goor et al.; J. Exp. Med. vol. 126, No. 5, pp. 923-939, 1967; "Studies on the Mode of Action of Diphtheria Toxin".
"Block of Light Responses of Salamander Rods by Pertussis Toxin and Reversal by Nicotinamide", G. Falk & R. A. Shiells, vol. 229, No. 1, pp. 131-134, FEBS Letters.
Guerrant, "Microbial Toxins and Diarrhoeal Disease" (Ciba Foundation Symposium 112, 1985, Pitman, London).
Goor et al., J. Exp. Med. 126 (1967), pp. 923-939.
Gill et al., "Microbial Toxins and Diarrhoeal Disease", Ciba Foundation Symposium 112, 1985, Pitman, London, pp. 57-69.

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