Preterm labor and membrane rupture test

Details Preterm labor and membrane rupture test Preterm labor and membrane rupture test

1988-09-15

1992-03-17

Rosen, Sam

Chemistry: analytical and immunological testing

Pregnancy or ovulation

436 63, 436510, 436518, 436547, 436548, 436814, G01N 3348

Patent

active

050968300

ABSTRACT:
A method for determining increased risk of labor and fetal membrane rupture after week 20 of pregnancy comprises obtaining a secretion sample from the vaginal cavity; and determining the presence of a fetal restricted antigen in the sample. The sample can be removed from anywhere in the vaginal cavity, but is preferably removed from the posterior fornix or and/or cervical os. One fetal restricted antigen is fetal fibronectin. In one embodiment of this invention, the sample is contacted with an insoluble support to which anti-(fetal restricted antigen) antibody is adhered, and the fetal restricted antigen binding to the support is determined. Alternatively, the class of substances of which the fetal restricted antigen is a member is captured with a general binding antibody (such as anti-human fibronectin antibody), anti-(fetal restricted antigen) antibody (such as anti-fetal fibronectin antibody) is conjugated with the support, and binding with fetal restricted antigen is determined.
Reagents and reagent kits are also included.

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