Pretargeting protocols for enhanced localization of active agent

Details Pretargeting protocols for enhanced localization of active agent Pretargeting protocols for enhanced localization of active agent

1994-10-26

1999-06-15

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 153, 424 145, 4241781, 4241811, 4241831, 4241791, 530367, 530350, 530825, 5303919, 5303915, 514387, 5483037, A61K 5100

Patent

active

059119691

ABSTRACT:
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for improved radiohalogenation of biotin, as well as related compounds, are described. Also, clearing agents, anti-ligand-targeting moiety conjugates, target cell retention enhancing moieties and additional methods are discussed.

REFERENCES:
patent: 4863713 (1989-09-01), Goodwin et al.
patent: 4885172 (1989-12-01), Bally et al.
patent: 4948590 (1990-08-01), Hawrot et al.
patent: 5047245 (1991-09-01), Bally et al.
patent: 5106951 (1992-04-01), Morgan, Jr. et al.
patent: 5112953 (1992-05-01), Gustavson
patent: 5120525 (1992-06-01), Goldenberg
patent: 5252713 (1993-10-01), Morgan, Jr. et al.
patent: 5273743 (1993-12-01), Ahlem et al.
patent: 5283342 (1994-02-01), Gustavson et al.
patent: 5326778 (1994-07-01), Rosebrough
patent: 5328985 (1994-07-01), Sano et al.
Goldrosen et al., Canc. Res., 1990, 50:7973.
Osband, Immunol Today, 1990, 11:193.
Chatterjee, Cancer Immunol. Immunother., 1994, 38:75.
Zwierzina, Stem Cells, 1993, 11:144.
Curti, Critical. Rev. Oncol. Hematol., 1993, 14:29.
Jain, 271(1):58, Scientific Am., 1994.
Galli, J. Nucl. Med., 32(2):110, 1988.
Morrell, J. Biol. Chem., 246(5) 1461, 1971.
Hind et al., 1990, Genes & Cancer, pp. 183-189, Immunotherapy . . . Antibodies.
Harris et al., 1993, Tibtech, 11:42, Therapeutic . . . Age.
Houghton et al., 1986, Semin. Oncology, 13:165, Monoclonal . . . Cancer.
Kalofonos et al., 1990, J. Nucl. Med., 31:1791, Imaging . . . Communication.
Hnatowich et al., 1987, J. Nucl. Med., 28:1294, Investigations . . . Applications.
Morrison et al., Hospital Practice, 24(10):65, 1989.
Darnell, Molecular Biology of the Cell, pp. 654-655, 1986.
Sheldon et al., Appl. Radiat. Isot., vol. 43, pp. 1399-1402, "Targeting of Covalent Monoclonal Antibody-Streptavidin Conjugates."
Goodwin, J. Nucl. Med., vol. 33, No. 10, pp. 1816-1818, "New Methods for Localizing Infection: A role for Avidin-Biotin?".
Goodwin et al., J. Nucl. Med., vol. 33, No. 11, pp. 2006-2013, "Pretargeted Immunoscintigraphy: Effect of Hapten Valency on Murine Tumor Uptake."
Glennie et al., Preparation and Performance of Bispecific F(ab'y).sub.2 Antibody Containing Thioether-Linked Fab'y Fragments.sup.1, Oct. 1, 1987, pp. 2367-2375.
Spooner et al., Tibtech, 1990, 8:189.
Blakeslee, The Toronto Globe and Mail, 1989.
Van Der Sluijs et al., Hepatology, vol. 6, No. 4, pp. 723-728, 1986, "Drug Targeting to the liver with lactosylated albumins: does the glycoprotein target the drug or is the drug targeting the glycoprotein?".
Virzi et al., Nucl. Med. Biol., vol. 18, No. 7, pp. 719-726, 1991, "New Indium-111 Labeled Biotin Derivates for Improved Immunotargeting."
Wilchek et al., Analytical Biochemistry, 1988, 171:1.

Affiliated with

Also associated with

Rating

Pretargeting protocols for enhanced localization of active agent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pretargeting protocols for enhanced localization of active agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pretargeting protocols for enhanced localization of active agent will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-400823