Preserved, non-infectious control cells prepared by the modulati

Details Preserved, non-infectious control cells prepared by the modulati Preserved, non-infectious control cells prepared by the modulati

1993-06-08

1995-04-25

Knode, Marian

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 29, 435 2, 536124, 436 10, A01N 102, C12N 508, G01N 3100

Patent

active

054098262

ABSTRACT:
The invention describes the preparation of preserved, non-infectious control cells. The control cells are prepared by modification, activation or otherwise changing selected normal leukocyte cells, tissue culture cells or zenogenic transplants in immunosuppressed animals to have characteristics of abnormal cells or by the addition of cells from an established cell line, which has been similarly modified or activated, to a normal leukocyte population. The preferred method of preserving the control cells is by lyophilization using an isotonic 10% trehalose solution.

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patent: 5059518 (1991-10-01), Kortright et al.
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Dustin M L et al, J. Immunol 137:245-54 (1986).
Evans H J et al, Nature 284:370-2 (1980).

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