Preserved, non-infectious control cells prepared by the modulati

Details Preserved, non-infectious control cells prepared by the modulati Preserved, non-infectious control cells prepared by the modulati

1995-04-10

1997-04-22

Naff, David M.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 2, 435 721, 435347, 536124, 436 10, A01N 102, C12N 508, G01N 3100

Patent

active

056228554

ABSTRACT:
The invention describes the preparation of preserved, non-infectious control cells. The control cells are prepared by modification, activation or otherwise changing selected normal leukocyte cells, tissue culture cells or zenogenic transplants in immunosuppressed animals to have characteristics of abnormal cells or by the addition of cells from an established cell line, which have been similarly modified or activated, to a normal leukocyte population. The preferred method of preserving the control cells is by lyophilization using an isotonic 10% trehalose solution.

REFERENCES:
patent: 4489162 (1984-12-01), Hawkins et al.
patent: 4867908 (1989-09-01), Recktenwald et al.
patent: 4876189 (1989-10-01), Schetters et al.
patent: 5059518 (1991-10-01), Kortright et al.
Fackler et al, 9BC 267:17540-6 (1992).

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