Preservative for use in calibrator compositions for blood analys

Compositions – Nonreactive analytical – testing – or indicating compositions

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23230B, 424 3, 424101, G01N 3316

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active

042500516

ABSTRACT:
A stable calibrator composition, useful in equipment for determining hematological values in blood samples, comprises a hemolysate of red blood cells which have been lysed with a dilute aqueous solution of saponin to which has been added a halophenol that has a phenol coefficient of between 20 and 90 to provide a concentration from about 1:1000 to about 1:1750 w/v of said halophenol in said hemolysate, said calibrator composition having a pH between 4 and 7. The preferred halophenol is 4-chloro-3,5-xylenol.

REFERENCES:
patent: 3000836 (1961-09-01), Ginsburg
patent: 3406121 (1968-10-01), Jones
patent: 3446751 (1969-05-01), Weichselbaum
patent: 3519572 (1970-07-01), Kita
patent: 3558522 (1971-01-01), Louderback et al.
patent: 3574137 (1971-04-01), DeCasperis
patent: 3632735 (1972-01-01), Kita
patent: 3640896 (1972-02-01), DeCasperis
patent: 3873467 (1975-03-01), Hunt
patent: 3884579 (1975-05-01), Mauthner
patent: 3918905 (1975-11-01), Warren et al.
patent: 3977995 (1976-08-01), Louderback et al.
patent: 4102810 (1978-07-01), Armstrong
"The Merck Index", 8th Ed., Merck & Co., Inc., Rahway, N.J., pp. 241-242, pp. 244-245, p. 249 (1968). _

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