Preservation of blood platelets

Chemical apparatus and process disinfecting – deodorizing – preser – Control element responsive to a sensed operating condition

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

436 8, 436 16, 435 2, 424532, G01N 3349

Patent

active

058766766

ABSTRACT:
Methods and compositions for preserving platelets at cryogenic temperatures with retention of hemostatic activity are provided. The compositions include a first agent for inhibiting actin filament severing and a second agent for inhibiting actin polymerization. Contacting the platelets with the first and second agents prior to exposure to cold temperature prevents cold-induced platelet activation.

REFERENCES:
patent: 3890435 (1975-06-01), Broadbent et al.
patent: 4412835 (1983-11-01), Spencer
patent: 4603209 (1986-07-01), Tsien et al.
patent: 5071741 (1991-12-01), Brockbank
patent: 5114847 (1992-05-01), Jungfer et al.
patent: 5185160 (1993-02-01), Chao
patent: 5190880 (1993-03-01), Cassou et al.
patent: 5234808 (1993-08-01), Murphy et al.
Cohen et al, Platelet Preservation, vol. 273, No. 16, "Comparison of Radioactivity Yields of Platelet Concentrates Derived from Blood Anticoaqulated with EDTA and ACD".
Gottschall et al, Transfusion, vol. 26, No. 5 (1986) "Studies of the minimum temperature at which human platelets can be stored with full maintenance of viability".
Remington's Pharmaceutical Sciences, Gennaro et al, Philadelphia College of Pharmacy and Science, (1990), pp. 800-803.
Principles of Transfusion Medicine, Rossi, et al, Williams & Wilkins, (1991), pp. 205-207, 212.
Blood Transfusion in Clinical Medicine, Mollison et al, Blackwell Scientific Publications, (1993), p. 642.
Hematology (Fourth Edition), Williams et al, McGraw-Hill Publishing Company, (1990), pp. 368-377 and 1233-1250.
Hematology, Basic Principles and Practice, Hoffman et al, Churchill Livingstone, (1991), pp. 1176-1197.
Physical Chemistry, Atkins, P.W., W.H. Freeman and Company, San Francisco, CA, (1982), p. 935.
Cassimeris, L. et al., J. Cell Biol. 110:1067-1075, "Chemoattractant-Stimulated Polymorphonuclear Leukocytes Contain Two Populations of Actin Filaments that Differ in Their Spatial Distributions and Relative Stabilities".
McManus, M.J. et al., Am. J. Physiol. 265:C562-570 (1993), "Laser light-scattering system for studying cell volume regulation and membrane transport processes".
Hartwig, J., 1992 J. Cell Biology 118 (6): 1421-1442, "Mechanisms of Actin Rearrangements Mediating Platelet Activation".
Hartwig, J. and DeSisto, M., 1991 J. Cell Biol. 112:407-425. "The Cytoskeleton of the Resting Human Blood Platelet: Structure of the Membrane Skeleton and Its Attachment to Actin Filaments".
Yin, H.L., 1987 BioEssays 7:176-179, "Gelsolin: Calcium- and Polyphosphoinositide-Regulated Actin-Modulating Protein".
Stossel, T., 1989 J. Biol. Chem. 264:18261-18264. "From Signal to Pseudopod--How Cells Control Cytoplasmic Actin Assembly".
Janmey, P.A., et al., 1985 Biochemistry 24:3714-3723. "Interactions of Gelsolin and Gelsolin-Actin Complexes with Actin Effects of Calcium on Actin Nucleation, Filament Severing, and End Blocking".
Davies, T.D., et al., 1989 J. Biol. Chem. 264:19600-19606, "Cytoplasmic Ca.sup.2+ Is Necessary for Thrombin-induced Platelet Activation".
Cobbold, P. and Rink, T., 1987 Biochem. J. 248:313-328. "Fluorescence and bioluminescence measurement of cytoplasmic free calcium".
R. Haugland, Handbook of Fluorescent Probes and Research Chemicals, 5th Edition, 1992-1994.
White, J.B. and Krivit, W., 1967 Blood 30:625-635, "An Ultra-structural Basis for the Shape Changes Induced in Platelets By Chilling".
White, J.G., 1982 Am. J. Path. 108:184-195, "Influence of Taxol on the Response of Platelets to Chilling".
Schliwa, M., 1982 J. Cell. Biol. 92:79-91. Action of Cytochalasin D on Cytoskeletal Networks.
Mooseker, M.S., 1986 J. Cell Biol. 102:282-288. "Cytochalasin B Slows But Does Not Prevent Monomer Addition at the Barbed End of the Actin Filament".
Lin et al., 1980 J. Cell. Biol. 84:455-460. Cytochalasins Inhibit Nuclei-Induced Actin Polymerization By Blocking Filament Elongation.
Ohmori, H., et al., 1992, J. Cell Biol. 116(4):933-941. Direct Proof That the Primary Site of Action of Cytochalasin on Cell Motility Processes Is Actin.
Cooper, J.A., 1987 J. Cell Biol. 105:1473-1478. Effects of Cytochalasin and Phalloidin on Actin.
Spector, I., et al., 1989 Cell Motility and the Cytoskeleton 13: 127-144. Latrunculins-Novel Marine Macrolides That Disrupt Microfilament Organization and Affect Cell Growth: 1. Comparison With Cytochalasin D.
Bennett, J.S. and Shattil, S.J., 1990, "Platelet function," Hematology, Williams, W.J., et al., Eds. McGraw Hill, pp. 1233-1250.
Slichter, S.J., 1981 Vox Sang 40 (Suppl 1), pp. 72-86, Clinical Testing and Laboratory-Clinical Correlations.
Murphy, P.H. and Gardener F.H., 1969 N. Engl. J. Med. 280:1094-1098. "Platelet Preservation--Effect of Storage Temperature on Maintenance of Platelet Viability--Deleterious . . . Storage".
Handin, R.I. and Valeri, C.R., 1971 N. Engl. Med. 285:538-543. "Hemostatic Effectiveness of Platelets Stored at 22.degree. C.".
Tsien, R., et al., (1982) J. Cell. Biol. 94:325-334. Calcium Homeostasis in Intact Lymphocytes: Cytoplasmic Free Calcium Monitored With a New, Intracellularly Trapped Fluorescent Indicator.
Janmey, P. and Stossel, T., 1987 Nature 325:362-364. Modulation of Gelsolin function by phosphatidylinositol 4,5-bisphosphate.
Janmey, P., et al., 1987 J. Biol. Chem. 262:1228-1232. "Polyphosphoinositide Micelles and Polyphosphoinositide-containing Vesicles . . . of Actin Filaments Blocked by Gelsolin".
Tsuyruo, et al., 1986 Biochem. Pharmacol. 35:1087-1090, "Effects of Cytochalasins and Colchicine on the Accumulation and Retention of Daunomycin and Vincristine in Drug Resistant Tumor Cells".
Lipski, K. et al. 1987 Anal. Biochem. 161:332-340, Cytochalasin B Preparation, Analysis in Tissue Extracts, and Pharmacokinetics after Intraperitonea Bolus Administration in Mice.
Janmey, P.A., and Stossel, T., 1989 J. Biol. Chem., 264:4825-4831 "Gelsolin-Polyphosphoinositide Interaction".
Janmey, P.A. et al., 1992 J. Biol. Chem. 267:11818-11823. "Phosphoinositide-binding Peptides Derived from the Sequences of Gelsolin and Villin".
Kwiatkowski, O.J., et al., 1989 J. Cell. Biol. 108:1717-1726. Identification of Critical Functional and Regulatory Domains in Gelsolin.
Way, et al. 1989 J. Cell. Biol. 109:593-605, "Expression of Human Plasma Gelsolin in Escherichia coli and Dissection of Actin Binding Sites by Segmental Deletion Mutagenesis".
Hartwig, J.H. and Kwiatkowski, O.J., 1991 Curr. Opin Cell Biol. 3:87-97, Actin-binding proteins.
Vanderkerkhove, J. and Vancompernolle, K., 1992 Curr. Opion Cell. Biol. 4:36-42, Structural relationships of actin-binding proteins.
Aktories, K. and Wegner, A., 1989 J. Cell Biol. 109:1385. ADP-ribosylation of Actin by Clostridial Toxins.
Hartwig, J. and Janmey, P. 1989 Biochim. Biophys. Acta 1010:64-71 Stimulation of a calcium-dependent actin nucleation activity by phorbol 12-myristate 13-acetate in rabbit macrophage cytoskeletons.
Hartwig, J., et al. 1989 J. Cell Biol. 109:1571-1579, Association of Profilin with Filament-free Regions of Human Leukocyte and Platelet Membranes and Reversible Membrane Binding during Platelet Activation.
Casella, J., et al, 1981 Nature (Lond.) 293:302-305, "Cytochalasin D inhibits actin polymerization and induces depolymerization of actin filaments formed during platelet shape change".
Fox, J. and D. Phillips, 1981 Nature (Lond.) 292:650-652, "Inhibition of actin polymerization in blood platelets by cytochalasins".
Schliwa, M., et al., 1981 Proc. Natl. Acad. Sci. USA 78:4329-4333, 5417-5420, Stabilization of the cytoplasmic ground substance in detergent-opened cells and a structural and biochemical analysis of its composition.
Howard, T.H. and Oresajo, J., 1987 Cell Motility and the Cytoskeleton 5:545-557, "A Method for Quantifying F-Actin in Chemotactic Peptide Activated Neutrophils: Sutdy of the Effect of of tBOC Peptide".
Zucker, M.B. and Borrelli, J., 1954 Blood 9:602, "Reversible terations in Platelet Morphology Produced by Anticoagulants and by Cold".
Handin, R.I. et al., 1970 Transfusion 10:305, Platelet Response to Hypotonic Stress after Storage at 4 C or 22 C.
Tsien, R., 1980 Biochemistry 19:2396-2404, "New Calcium Indicators and Buffers with High Selectivity against Magnes

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Preservation of blood platelets does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preservation of blood platelets, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preservation of blood platelets will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-419388

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.