Preservation and restoration of hemoglobin in blood substitutes

Details Preservation and restoration of hemoglobin in blood substitutes Preservation and restoration of hemoglobin in blood substitutes

1988-08-09

1991-09-24

Lone, Werren B.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

A01N 100

Patent

active

050513532

ABSTRACT:
A hemoglobin-containing blood substitute preparation is protected from oxtion to methemoglobin. The protected preparation comprises between 10 mM and 60 mM of a compound selected from the group consisting of glutathione (GSH), nicotinamide adenine dinucleotide (NADH), nicotine adenine dinucleotide phosphate (NADPH) and mixtures of these in the aqueous phase of a hemoglobin-containing fluid. Oxidized hemoglobin in a preparation can be restored by adding between 10 mM and 60 mM of a compound selected from the group consisting of glutathione (GSH), nicotinamide adenine dinucleotide (NADH), nicotine adenine dinucleotide phosphate (NADPH) and mixtures of these to a hemoglobin-containing fluid in which the hemoglobin has converted in whole or part to methemoglobin, and storing the fluid at storage temperatures for blood products above the freezing point of the fluid for a time sufficient to convert methemoglobin to hemoglobin.

REFERENCES:
patent: 4425334 (1984-01-01), Hunt
patent: 4675310 (1987-06-01), Chapman et al.

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