Preseparation processor for use in capillary electrophoresis

Details Preseparation processor for use in capillary electrophoresis Preseparation processor for use in capillary electrophoresis

1995-04-17

1998-09-01

Gorgos, Kathryn L.

Chemistry: electrical and wave energy

Apparatus

Electrophoretic or electro-osmotic apparatus

204451, 204453, 204604, G01N 2726, G01N 27447

Patent

active

058006923

ABSTRACT:
A preseparation processor for use in capillary electrophoresis is described. The preseparation processor contains sample processing material, preferably in the form of a membrane, for use in concentrating or chemically processing a sample, or catalyzing a chemical reaction. It is particularly suited to the concentration of dilute samples or the purification of contaminated samples. The preseparation processor facilitates reliable and reproducible separation of analytes by eliminating inconsistencies caused by a reversal of the electroosmotic flow otherwise induced by the sample processing material.

REFERENCES:
patent: 4705616 (1987-11-01), Andresen et al.
patent: 4708782 (1987-11-01), Andresen et al.
patent: 4842701 (1989-06-01), Smith et al.
patent: 4865707 (1989-09-01), Karger et al.
patent: 4885076 (1989-12-01), Smith et al.
patent: 4895806 (1990-01-01), Le et al.
patent: 4911807 (1990-03-01), Burd
patent: 4997530 (1991-03-01), Ellis et al.
patent: 5006313 (1991-04-01), Swedberg
patent: 5084150 (1992-01-01), Karger et al.
patent: 5089106 (1992-02-01), Karger et al.
patent: 5126025 (1992-06-01), Carson et al.
patent: 5131998 (1992-07-01), Jorgenson et al.
patent: 5151164 (1992-09-01), Blanchard et al.
patent: 5169510 (1992-12-01), Lunte et al.
patent: 5169511 (1992-12-01), Allington et al.
patent: 5180475 (1993-01-01), Young et al.
patent: 5202010 (1993-04-01), Guzman
patent: 5213669 (1993-05-01), Guttman
patent: 5228960 (1993-07-01), Liu et al.
patent: 5240585 (1993-08-01), Young et al.
patent: 5246577 (1993-09-01), Fuchs et al.
patent: 5262031 (1993-11-01), Lux et al.
patent: 5282941 (1994-02-01), Rose, Jr.
patent: 5290587 (1994-03-01), Young et al.
patent: 5318680 (1994-06-01), Fishman et al.
patent: 5340452 (1994-08-01), Brenner et al.
Liyuan Bao and Purnendu K. Dasgupta, "Membrane Interfaces for Sample Introduction in Capillary Zone Electrophoresis" Analytical Chemistry, vol. 64, No. 9 (May 1, 1992) 991-996.
Fang et al., "On-line Time-of-Flight Mass Spectrometric Analysis of Peptides Separated by Capillary Electrophoresis", Anal. Chem., 66, 3696-3701 (1994).
Swartz et al., "On-line Sample Preconcentration on a Packard-Inlet Capillary for Improving the Sensitivity of Capillary Electrophoretic Analysis of Pharmaceuticals", J. Chromatogr., 632, 209-213 (1993).
Tomlinson et al., "On-Line Preconcentration-Capillary Electrophoresis-Mass Spectrometry (PC-CE-MS)", Journal of High Resolution Chromatography, 17, 729-731 (Oct. 1994).
Linda M. Benson et al., "Time Course Analysis of a Microsomal Incubation of a Therapeutic Drug Using Preconcentration Capillary Electrophoresis (PE-CE)," Journal of High Resolution Chromatography,vol. 17, pp. 3-5, No month available (1994).
R-L. Chien et al., "Field amplified sample injection in high-performance capillary electrophoresis", Journal of Chromatography, 559, pp. 141-152, No month available (1991).
P. D. G. Dean et al., "Electrophoretic Desorption of Affinity Adsorbents", Biochemical Society Transaction 569th Meeting, Sussex, vol. 5, pp. 1111-1113 No date available.
A. J. J. Debets et al., "Switching valve with internal micro precolumn for on-line sample enrichment in capillary zone electrophoresis," Journal of Chromatography, 608, pp. 151-158, No month available (1992).
N. A. Guzman et al., "The Use of a Concentration Step to Collect Urinary Components Separated by Capillary Electrophoresis and Further Characterization of Collected Analytes by Mass Spectrometry", Journal of Liquid Chromatography, 14(5), pp. 997-1015, No month available (1991).
S. C. Jacobson et al., "Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices", Analytical Chemisry, vol. 66, No. 7, pp. 1107-1113, No month available (1994).
V. Kasicka et al., "Desorption Isotachophoresis--Quantitative Characterization of Sorption and Desorption Conditions", Journal of Chromatography, pp. 75-80, No month available (1985).
V. Kasicka et al., "Determination of Dissociation Constants of Weak Electrolytes by Capillary Isotachophoresis", Journal of Chromatography, pp. 33-43, No month available (1985).
V. Kasicka et al., "Isotachophoretic Electrodesorption of Proteins From an Affinity Adsorbent on a Microscale", Journal of Chromatography, 273, pp. 117-128.
J. Mark, "Use of a Poroszyme.TM. Immobilized Trypsin Cartridge for Peptide Mapping" PerSeptive Biosystems, No month available (1994).
Master Bond Inc., "Material Safety Data Sheet, A Solvent-Free, Two Component High Performance Epoxy Adhesive/sealant Featuring Resistance to Radiation, Ethylene Oxide & Steam Sterilization, Meeting USP Class VI Requirement", U.S. Department of Labor, OSHA 174, No month available (1985).
R. Nelson et al., "Temperature Control in Capillary Electrophoresis," CRC Handbook of Capillary Electrophoresis, pp. 549-562, 1994. No date available.
L. Netzer et al., "Adsorbed Monolayers Versus Langmuir-Blodgett Monolayers--Why and How? 1: From Monolayer to Multilayer, By Adsorption", Thin Solid Films, 99, pp. 235-241, No month available (1983).
Robert P. Oda et al., "Introduction to Capillary Electrophoresis," CRC Handbook of Capillary Electrophoresis, pp. 25-28, No month available (1994).
Z. Prusik et al., "Micropreparative Isotachophoretic Electrodesorption of Monoclonal Antibodies From an Affinity Adsorbent", Journal of Chromatography, 320, pp. 81-88, No month available (1985).
W. J. Storkus et al., "Identification of T-Cell Epitopes: Rapid Isolation of Class I-Presented Peptides from Viable Cells by Mild Acid Elution" Journal of Immunotheraphy, 14, pp. 94-103 No month available (1993).
A.J. Tomlinson et al., "Effects of Organic Solvent in the CE and On-Line CE-MS Analysis of Drug Metabolite Mixtures," American Laboratory, pp. 29-36, (Jun. 1994).
A. Tomlinson et al., "MHC Class I Peptides, Strategy for Isolation and Sequencing of MHC Class I Peptides Using Capillary Electrophoresis and Capillary Electrophoresis-Mass Spectrometry/Mass Spectrometry", HPCE '94 Conference in San Diego, CA., No month available (1994).
A. J. Tomlinson et al., "Analysis of Biologically Derived Biopolymers and Drug Metabilites by Preconcentration-Capillary Electrophoresis-MS", ASMS '94, No month available (1994).
A. J. Tomlinson et al., "Modification of Electroosmotic Flow in Preconcentration-Capillary Electrophoresis (PC-CE", Journal of High Resolution Chromatography vol. 17, pp. 1-3, No month available (1994).
The United States Pharmacopeia, The National Formulary, Biological Tests, Biological Reactivity Tests, In Vivo, vol. 88, pp. 1699-1703, No month available (1995).
3M and Varian International AG, "Empore.TM. Extraction Disks for Environmental Analysis", Technical Data Brochure No date available.
B.J. Wanders et al., "Isotachophoresis in Capillary Electrophoresis," CRC Handbook of Capillary Electrophoresis, pp. 111-127, No month available (1994).

Affiliated with

Also associated with

Rating

Preseparation processor for use in capillary electrophoresis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preseparation processor for use in capillary electrophoresis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preseparation processor for use in capillary electrophoresis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-266405