Preparing vaccine against Herpes simplex virus

Details Preparing vaccine against Herpes simplex virus Preparing vaccine against Herpes simplex virus

1983-03-24

1989-03-28

Marantz, Sidney

Drug, bio-affecting and body treating compositions

Lymphokine

435235, 435237, 435238, A61K 39245

Patent

active

048162507

ABSTRACT:
A vaccine against a DNA virus, for exmaple, Herpes simplex virus, is prepared by incubating a cell sample which has been infected with the virus, releasing the nuclei in the infected cell material from the cytoplasmic fraction of that material, chemically fixing the polypeptide chains in the cytoplasmic fraction, and forming a precipitate which includes the virus antigens in the cytoplasmic fraction, the precipitate providing the active constituent of the vaccine. A characteristic strain of the virus is preferred, and transfers its characteristics to the vaccine so that vaccinated subjects may subsequently be distinguished from infected subjects.

REFERENCES:
patent: 4317811 (1982-03-01), Bertland et al.
patent: 4452734 (1984-06-01), Larson et al.
Skinner et al., Br. J. Exp. Path., vol. 63, No. 2, pp. 378-387 (1982).
Skinner et al., Br. J. Ven. Dis., vol. 58, No. 6, pp. 381-386 (1982).
Skinner et al., Med. Microbiol. Immunol. 169, 39-51 (1980).
Muramatsu, "Isolation of Nuclei and Nucleoli", Cell Physiology, IV, pp. 195-228, 1981.
Alberts et al., "Molecular Biology of the Cell", Garland Publishing Company, New York, 1983, p. 145.
Glauret, "Practical Methods in Electron Microscopy", North-Holland Publishing Company, Amsterdam, 1975, p. 44.
Heide et al., "Plasma Protein Fractionation", The Plasma Proteins, vol. 3, Academic Press, New York, 1977, pp. 548-550.
Harris, "Techniques in Experimental Virology", Academic Press, 1964, p. 157.
Pearson et al., Proc. Natl. Acad. Sci., 74, 2546-2550 (1977), "Isolation of Virus-Free Herpesvirus Saimiri Antigen-Positive Plasma Membrane Vesicles".

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