Preparing pyrazolopyrimidinone derivatives for the treatment...

Details Preparing pyrazolopyrimidinone derivatives for the treatment... Preparing pyrazolopyrimidinone derivatives for the treatment...

2005-01-18

2005-01-18

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

Reexamination Certificate

active

06844436

ABSTRACT:
A method for preparing pyrazolopyrimidinone derivatives and their pharmaceutically acceptable salts having efficacy on the treatment of impotence, one of male sexual dysfunctions. The method comprises the steps of: a) chlorosulfonating a pyrazolamide compound to obtain a chlorosulfonated compound; b) reacting the chlorosulfonated compound of step (a) with a primary amine to obtain a sulfonamide compound and c) performing an intramolecular cyclization of the sulfonamide compound of step (b) to produce the compound of formula below 1, wherein the steps b) and c) are performed in situ in alcohol by adding a base to the reaction mixture without workup after the step b) is completed.

REFERENCES:
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Reusch, William, “Virtual Textbook of Organic Chemistry” Michigan State University, [retrieved on Mar. 2, 2004]. Retrieved from the internet, <http://www.cem.msu.edu/˜reusch/VirtualText/amine1.htm>.*
Fu et al, CN 1,246,478, 2000, cited in Chemical Abstracts, AN 133:281797 CASREACT.*
Fu et al, CN 1,246,478, Mar. 8, 2000, English translation PTO 04-2259.

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