Preparing method for controlled released type tablet...

Details Preparing method for controlled released type tablet... Preparing method for controlled released type tablet...

2008-01-01

2008-01-01

Pak, John (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C424S472000, C424S482000, C514S603000, C514S786000, C514S960000, C514S961000, C514S964000

Reexamination Certificate

active

07314638

ABSTRACT:
The present invention relates to a simple and effective method for preparing a tamsulosin HCl sustained-release tablet and a tamsulosin HCl sustained-release tablet produced thereby. The method comprises the steps of: dissolving tamsulosin HCl as an active ingredient in an organic solvent; dissolving the tamsulosin HCl solution in hydroxypropylmethylcellulose phthalate to prepare a binder solution; and kneading the binder solution with a hydroxypropylmethylcellulose phthalate/glyceryl dibehenate mixture as an excipient and allows tamsulosin HCl to be released at uniformly controlled amounts in a subtained-release manner in vivo by controlling drug release rate according to different pH environments in vivo, so that it shows improved bioavailability and minimized side effects.

REFERENCES:
patent: 4772475 (1988-09-01), Fukui et al.
patent: 6569463 (2003-05-01), Patel et al.
patent: 7255876 (2007-08-01), Shinoda et al.
patent: 2003/0064097 (2003-04-01), Patel et al.
patent: 2007/0196500 (2007-08-01), Woo et al.
Derwent abstract 2003-565433; abstracting KR 2002063753 (2002).
HCAPLUS abstract 2004:969522; abstracting KR 2002063753 (2002).
Medline abstract 2007132208 (2007).

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