Preparing glutathione monoesters

Details Preparing glutathione monoesters Preparing glutathione monoesters

1989-07-14

1992-03-03

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Tripeptides, e.g., tripeptide thyroliberin , etc.

530345, 560 40, 560 41, A61K 3702

Patent

active

050934783

ABSTRACT:
In the esterification of glutathione with alcohol in the presence of acid catalyst, neutral glutathione monoester is isolated in high yields without the intermedite isolation of ester acid salt by treating the reaction mixture with base anion exchange resin (basic form) to neutralize the acid and bind the resulting acid anion and unesterified glutatione. Dehydrating agent is used to drive the reaction toward esterification. In the production of glutathione monester acid salts a soluble dehydrating agent is advantageously used.

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patent: 4709013 (1987-11-01), Nagano
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Morrison & Boyd 3rd Ed. Organic Chemistry (Allyn & Bacon 1973) 602-603.
Freifelder, 2nd Ed. Physical Biochemistry (Freeman & Co. 1982) at 248-257.
Wharton & McCarty, Experiments and Methods in Biochemistry (Macmillan Co. 1972) at 101-105.
Diaion Data Sheet High Porous Polymer HP Series, Mitsubishi Chemical Industries, Ltd, 3/85.

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