Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2007-05-18
2011-12-13
Katakam, Sudhakar (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C562S401000, C562S402000, C562S400000, C562S405000, C562S579000
Reexamination Certificate
active
08076511
ABSTRACT:
High yields and purity are obtained in the purification of enantiomers of chiral carboxylic acids by preparative-scale chromatography by including a tertiary alcohol in the mobile phase in conjunction with an acidic modifier and a hydrophobic solvent. The tertiary alcohol is superior to other, more commonly used alcohols by reducing the extent of esterification of the enantiomer that otherwise lowers the yield and the purity.
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patent: WO 2006/011047 (2006-02-01), None
patent: WO 2006011047 (2006-02-01), None
Cia, Xiaojun et al.; “Enantioseparation of acidic compounds on chiral stationary phase by high performance liquid chromatography”; 2004,Fenxi Huaxue, vol. 32, No. 2, pp. 134-138.
Miller, Larry et al.; “Chromatographic resolution of the enantiomers of a pharmaceutical intermediate from the milligram to the kilogram scale”; 1999,Journal of Chromatography, vol. 849, pp. 309-317.
Xiaojun, Cai et al.; “Enahtioseparation of acidic compounds in chiral stationary phase by high performance liquid chromatography”; 2004,Chinese Journal of Analytical Chemistry, vol. 32, No. 2, pp. 134-138.
Berget Patrick
Dapremont Olivier
Her Xa
Huang Der-Shing
Sanchez Darin
Ampac Fine Chemicals LLC.
Heines M. Henry
Katakam Sudhakar
Kilpatrick Townsend & Stockton LLP.
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