Preparative liquid chromatograph using plural detectors

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample

Reexamination Certificate

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C422S089000, C210S198200, C210S656000, C095S082000, C096S101000, C096S102000, C073S023360, C073S023370, C073S061570, C073S061580, C702S022000, C702S023000, C702S024000, C702S025000, C436S161000, C436S164000, C436S173000

Reexamination Certificate

active

10617021

ABSTRACT:
The preparative liquid chromatograph uses a plurality of detectors including a mass spectrometer, and a chromatogram generator is provided for generating a plurality of chromatograms each corresponding to each of the plurality of detectors. The plurality of chromatograms are converted into a respective binary signal by comparing the chromatogram with a predetermined threshold, and a logical operator performs a binary operation on the plurality of respective binary signals, whereby a resultant binary signal is generated. A separation controller controls the fraction collector of the preparative liquid chromatograph based on the resultant binary signal to separate components from a sample. When “AND” is used as the binary operation, the resultant binary signal is “1” only when all the respective binary signals are “1”. This assures a high precision, high purity separation where an impurity mingling is minimized. When “OR” is adopted as the binary operation, the resultant binary signal is “1” when a component is detected by any of the plurality of detectors. This assures separation of as many components as possible appearing in the chromatograms generated by the detectors.

REFERENCES:
patent: 5670054 (1997-09-01), Kibbey et al.
patent: 5938932 (1999-08-01), Connelly et al.
patent: 6413431 (2002-07-01), Abedi
patent: 2002/0074490 (2002-06-01), Umemura
patent: 2002/0121468 (2002-09-01), Fischer et al.
patent: 1 162 456 (2001-12-01), None
patent: 53-4594 (1978-01-01), None
patent: 64-54351 (1989-03-01), None
patent: 3-29850 (1991-02-01), None
patent: 4-138358 (1992-05-01), None
patent: 4-326058 (1992-11-01), None
patent: 10-19868 (1998-01-01), None
patent: 10-197506 (1998-07-01), None
patent: WO 97/38303 (1997-10-01), None
patent: WO 99/25452 (1999-05-01), None
Kiplinger et al., Rapid Communications in Mass Spectrometry 12, 658-664 (1998).
Rosentreter et al, Journal of Combinatorial Chemistry, vol. 6, No. 2, 159-164 (Mar./Apr. 2004; published on Web Jan. 17, 2004).
Stevens et al. “A Multipurpose Preparative System for the Detection and Collection of Active and Non-Active UV/Vis Compounds” www.gilson.com.
Mazza, “Purification Solutions for Today's Scientists” PittCon 2005, Orlando, FL, Feb. 28, 2005.
Waters, Autopurification Systems Fractionlynx MS, Fractionlynx UV brochure, May 2001.
Zeng, L. et al., “Automated analytical/preparative high-performance liquid chromatography-mass spectrometry system for the rapid characterization and purification of compound libraries”, Journal of Chromatography A, Elsevier Science, NL, vol. 794, 1998, pp. 3-13.

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