Drug – bio-affecting and body treating compositions – Manicure or pedicure compositions
Patent
1998-02-11
1999-12-28
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Manicure or pedicure compositions
424405, A61K 704, A01N 2500
Patent
active
060077980
DESCRIPTION:
BRIEF SUMMARY
The invention relates to a nail varnish comprising a nail growth-promoting compound and a water-insoluble film-forming agent, to processes for its preparation and to the use thereof for the treatment of growth disturbances of the nail.
The nail plate which seals and protects the nail is a horny, hard appendage of the skin of the fingertip or tip of the toe which grows out of a pocket-like invagination of the epidermis on the finger or the back of the toe.
The formation of the nail material for the nail plate is effected primarily in the nail matrix, a specialized tissue which occupies the lower portion of the nail pocket from its proximal end up to the lunula. The nail matrix region is adjacent distally to the nail bed, with which the nail plate, which is structured in the form of a longitudinal strip on its under-surface, firmly adheres up to the hyponychium. The hyponychium is the dorsal region of the epidermis lying between the nail bed and finger pad.
The surface of the nail plate is smooth, and its color is a delicate pink as a result of corial capillaries showing through. Only an area 1-5 mm in size in the shape of a half-moon--the lunula--present at the proximal end looks whitish.
The growth rate of the nail plate, i.e. its increase in length beyond the free edge, depends on the extent of regeneration of nail cells in the nail matrix. The cell material formed there differentiates into plate-like horny structures which are passively pushed in the distal direction. The nail grows continuously throughout the entire life of the organism. The growth rate decreases with old age. The average weekly increase in length of the fingernails is 0.5 to 1.2 mm, and, in addition to age and sex, circulation, diet and physiological stress can have an influence on this value. The nails on the working hand are said to grow faster. Toenails grow significantly more slowly than fingernails, especially in older persons.
In the case of a normal nail growth rate of someone about 35 years old, the time needed for a new fingernail to grow out is about 6 months, and a toenail is regenerated in about 12 months.
In addition to constitutional factors which lead to an absence of nail growth, numerous local or general disease processes and also effects due to poisons, medicaments, chemicals and traumas can adversely influence the growth and appearance of the nail.
Nail growth plays a quite decisive role in the treatment and the required duration of treatment of onychomycoses; onychomycoses are understood as meaning infections of the nail bed which are caused by fungi and, as the duration of the disease increases, can extend over the entire nail, including the visible portion of the nail plate.
In the case of distal subungual onychomycoses, the clinical type to be observed most frequently, the pathogens attack the nail organ by first gaining access to the hyponychial horny layer. As the infection progresses further, the underside of the nail plate is also attacked. In later stages, discolorations and restructuring occur in the nail plate, as a result of which the appearance of the nail changes completely. Keratophilic fungi such as Trichophyton rubrum or T. mentagrophytes change the nail plate in a quite characteristic manner. They lead to a visible discoloration, which is accompanied by destruction of the lamellar structure of the nail plate in the progressing stage and finally leads to complete destruction of the protective shield. As the infection progresses, the subungual tissue debris of the hyponychium and of the nail bed is an ideal breeding ground for further microorganisms, which in turn contribute toward additional change in the chemical and physical properties of the underside of the nail plate. Finally, the nail plate initially becomes detached from the nail bed, which is associated with great pain for the patient when moved. Those affected can thus lose the entire nail plate due to the action of the fungi, so that only the hypokeratotic nail bed remains, which is thus rendered unprotected against external influences. Dir
REFERENCES:
patent: 4927626 (1990-05-01), DeVillez et al.
patent: 4957730 (1990-09-01), Bohn et al.
Bohn Manfred
Kraemer Karl Theodor
Ulbricht Horst
Hoechst Aktiengesellschaft
Howard Sharon
Page Thurman K.
LandOfFree
Preparations stimulating nail growth does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparations stimulating nail growth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparations stimulating nail growth will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2380401