Preparations of islet amyloid polypeptide (IAPP) and antibodies

Details Preparations of islet amyloid polypeptide (IAPP) and antibodies Preparations of islet amyloid polypeptide (IAPP) and antibodies

1990-04-30

1992-05-26

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530866, 530303, C07K 7100

Patent

active

051169487

ABSTRACT:
Islet Amyloid Polypeptide substantially free of Islet Amyloid which can be isolated from Islet Amyloid of different mammals and when isolated from humans it has the following amino acid sequence in positions 1-37: ##STR1##

REFERENCES:
Colin L. Masters, et al., Embo Journal 4(11): 2757-63, 1985, "Neuronal Origin of a . . . ".
K. A. Fackelmann, Science News 138:250-1, 1990, "Elusive Amylin".
T.-Y. Fang et al., Pancreas, 1, 293 (1986).
C. Betsholtz et al., Exper. Cell Res., 183, 484 (1989).
P. Westermark et al., Diabetologic, 24, 342 (1983).
T. D. O'Brien, Am. J. Pathol., 119, 430 (1985).
K. H. Johnson et al., Vet. Pathol., 22, 463 (1985).
K. Higuchi et al., Lab. Invest., 48, 231 (1983).
C. Betsholtz et al., Diabetes, 39, 118 (1990).
P. Westermark, PNAS U.S.A., 84, 3881 (Jun. 1987).
A. Clark, The Lancet, 231 (Aug. 1, 1987).

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