Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-12-28
1996-04-23
Warden, Jill
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
A61K 3800
Patent
active
055103294
ABSTRACT:
The invention relates to compositions which induce in humans regeneration of the corneal endothelium. The compositions of the invention are of value in regenerating the corneal endothelium in humans, which is frequently damaged in the course of eye surgery and injuries. Such regeneration is very important to ensure the full functionality of the eye. The compositions of the invention comprise as active ingredient an adequate quantity of fibroblast growth factor (FGF) in a suitable physiologically acceptable vehicle. A preferred embodiment of the invention relates to a composition containing a certain quantity of hyaluronic acid and any other viscoelastic agent.
REFERENCES:
patent: 4141973 (1979-02-01), Balazs
Sanion, Metab. Pediat. Syst. Ophthal., 6, 305, 1982.
Lee, Journal of Pharmaceutical Sciences, 63, No. 5, 721-724 (1974).
C87-081037 English Language Abstract of 62-122671 Japanese Patent, publis Jun. 1987.
Joseph A. Capella; Am. J. Ophthal., 74(5): 810-817, 1972.
N. Savion et al; Metal, Ped., and Syst. Ophthal. 6: 305-320, 1982.
"Fundamentals and Principles of Ophthalmology", Basic and Clinical Science Course, American Academy of Ophthalmology, pp. 53-56 (1988-1989).
Yue et al., "Growth of Human Corneal Endothelial Cells in Culture", Investigative Ophthalmology & Visual Science 30(2):248-253 (1989).
Belkin Michael
Landshman Nahum
Savion Naphtali
Huff Sheela J.
Ramot University for Applied Research and Industrial Development
Warden Jill
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