Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1993-12-17
1996-12-03
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514885, 514908, 549228, 549297, 549298, A61K 3578, C07D32100, C07D30777
Patent
active
055805620
ABSTRACT:
A Tripterygium wilfordii Hook F preparation having an improved LD.sub.50 in mice, an improved therapeutic activity:toxic index ratio and a lower amount of triptolide as compared to previous preparations is disclosed. The LD.sub.50 in mice of the T. wilfordii preparation is greater than about 860 mg/kg, the therapeutic activity:toxic index ratio is greater than about 2.6.times.10.sup.-3, and the amount of triptolide is less than about 1.3 .mu.g/mg. The preparation is useful for immunosuppression, in particular, the suppression of primary antibody response and suppression of autoimmune disease and for the treatment of rheumatoid arthritis.
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Cai Jian
Lipsky Peter E.
Tao Xue L.
Board of Regents , The University of Texas System
Lee Howard C.
Robinson Douglas W.
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