Preparation with collagenolytic activity having high activity an

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Multienzyme complexes or mixtures of enzymes

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424 50, A61K 3762, A61K 728

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active

047327588

ABSTRACT:
The invention relates to a pharmaceutical composition containing in association with a pharmaceutical vehicle a collagenase of high specific activity and capable of being inhibited at least partly by myosine. It is useful for the treatment of pathologies manifested by an uncontrolled alteration of the collagen-rich structures in man or animal.

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patent: 4329430 (1982-05-01), Klein et al.
patent: 4524065 (1985-06-01), Pinnell
patent: 4543329 (1985-09-01), Daum et al.
Keil et al., "Specificity of Collagenase from Achromobacter Iophagus", FEBS Letters, vol. 56, No. 2, Aug. 1975.
Microbiology Abstracts, vol. 11, No. 3, (1976-3), "Specificity of Collagenase from Acromobacter Iophagus", 11B2273, B. Keil et al.
Microbiology Abstracts, vol. 11, No. 3, (1976-3), "Purification, Stability and Inhibition of the Collagenase from Achromobacter Iophagus", 11B2274, A. Lecroisey et al.

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