Preparation process of N-acylphenylalanines

Details Preparation process of N-acylphenylalanines Preparation process of N-acylphenylalanines

1985-11-04

1987-06-23

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562445, 562446, 562447, 562450, 549441, C07C 9900

Patent

active

046754393

ABSTRACT:
A process for preparing an N-acylphenylalanine represented by the formula (II): ##STR1## wherein R.sub.3 and R.sub.4 mean individually a hydrogen atom or an alkyl, alkoxy, phenoxy, hydroxy or methylenedioxy group, and R denotes a methyl or phenyl group, which comprises catalytically reducing an N-acyl-.beta.-phenylserine represented by the formula (I): ##STR2## wherein R.sub.1 and R.sub.2 mean individually a hydrogen atom or an alkyl, alkoxy, phenoxy, benzyloxy or methylenedioxy group, and R has the same meaning as defined in the formula (II), in the presence of a reducing catalyst or both reducing catalyst and acid, in a solvent.

REFERENCES:
patent: 3010992 (1961-11-01), Brathga et al.
patent: 3488363 (1970-01-01), Hinkley
patent: 3517057 (1970-06-01), Pines et al.
patent: 3804894 (1974-04-01), Bernstein et al.
patent: 4261919 (1981-04-01), Knowles et al.
patent: 4480109 (1984-10-01), Ohashi et al.
Fieser et al., "Reagents for Organic Synthesis", pp. 778-779 (1967).

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