Preparation process of 2-chloropropionaldehyde

Details Preparation process of 2-chloropropionaldehyde Preparation process of 2-chloropropionaldehyde

1985-11-22

1987-03-31

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568455, C07C 4550

Patent

active

046544453

ABSTRACT:
This invention relates to a process for preparing 2-chloropropionaldehyde (2-CPA) by using vinyl chloride, carbon monoxide and hydrogen as raw materials. Although processes making use of cobalt catalysts have conventionally been known, it is disclosed herein that by using a rhodium compound and a nitrogen- or phosphorus-containing Lewis base in combination as a catalyst, the reaction is allowed to proceed at temperature and pressure lower than those required for such conventional processes and the selectively toward the intended product is improved. It is also disclosed that by causing water to exist in the reaction system and using a water-insoluble organic solvent, fractionating the reaction mixture into a water layer and an organic layer after the reaction and then collecting 2-CPA from the water layer through distillation, extraction or the like, the rhodium compound contained substantially in its entirety in an organic layer can be reutilized in the form of its solution. This process is an extremely good process suitable for use in the preparation of 2-CPA which is useful as an intermediate for chemical products, agricultural chemicals, pharmaceutical products, etc.

REFERENCES:
patent: 3239570 (1966-03-01), Slaugh et al.
patent: 4045492 (1977-08-01), Kniese et al.
patent: 4370504 (1983-01-01), Ojima et al.
patent: 4496769 (1985-01-01), Denise et al.
Helvetica Chimica Acta, 48(5) 1151-1157, 1965.
Tetrahedron Letters No. 22, 1725-1726, 1969.

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