Preparation process of 2-chloro pyrimidine

Details Preparation process of 2-chloro pyrimidine Preparation process of 2-chloro pyrimidine

1979-05-11

1980-10-07

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23930

Patent

active

042269954

ABSTRACT:
Preparation process of 2-chloro pyrimidine from 2-amino pyrimidine, hydrochloric acid and an alkali metal nitrite, the reagents being in substantially similar proportions as in the previously known methods, consisting in preparing a mixture of hydrochloric acid and of a non polar solvent of low boiling point, then adding 2-amino pyrimidine wherein there is slowly added, at room temperature, the chloride of a metal selected from the group consisting of the transition metals, tin, antimony, thallium and zinc, then introduced, under an inert gas circulation, the selected nitrite at a temperature not exceeding 10.degree. C. and finally poured the reaction mixture in iced water.

REFERENCES:
patent: 2477409 (1969-07-01), Howard
patent: 3711480 (1973-01-01), Ruetman

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