Preparation process for making water-soluble lysine salts of (+)

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D26356

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051208512

ABSTRACT:
Water-soluble salts of (+)2-(4-fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid with DL-lysine, D-lysine or L-lysine, suitable for the preparation of medicinal specialities such as syrups, creams, suppositories, aqueous solutions for personal hygiene etc, and their preparation process.
The salts are obtained by suspending said acid in an organic solvent soluble or partly soluble in water, adding an equivalent quantity of the lysine and crystallizing the salt obtained.

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patent: 4699927 (1987-10-01), De Boeck
patent: 4748174 (1988-05-01), Veronesi
patent: 4749694 (1988-07-01), Fix et al.
patent: 4797423 (1989-10-01), Benant
Chem. Abstr. Vol. 82, Entry 118774b, 1975.

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