Preparation of xanthine tracers

Details Preparation of xanthine tracers Preparation of xanthine tracers

1981-05-28

1983-08-09

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

544268, 544269, 544267, 544270, C07D47304

Patent

active

043977790

ABSTRACT:
Compounds useful as tracers in the radioimmunoassay of xanthine derivatives such as theophylline and pharmacologically related drugs: ##STR1## wherein at least one R.sub.1, R.sub.3, R.sub.7 or R.sub.8 is a radioiodinated radical and wherein, if not substituted by a radioiodinated radical, the remaining R.sub.1, R.sub.3, R.sub.7 or R.sub.8 groups are otherwise identical to the substituents at these positions in the xanthine derivative to be assayed. Ordinarily, R.sub.1 is hydrogen, acetate or methyl; R.sub.3 is methyl; R.sub.7 is hydrogen, acetate or methyl; and R.sub.8 is hydrogen. The tracers are made by linking radioiodinatable or preradioiodinated radicals to the xanthine derivative which is to be assayed. The tracers may be employed in known radioimmunoassay techniques.

REFERENCES:
patent: 4247453 (1981-01-01), Ali
patent: 4297263 (1981-10-01), Buckler et al.
patent: 4297494 (1981-10-01), Groman et al.

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