Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-10-09
1994-08-30
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546 48, 544 60, 544125, 544361, 540470, 540481, 540575, 540597, C07D491147
Patent
active
053429478
ABSTRACT:
The present invention relates to the synthesis of water soluble, camptothecin derivatives of formula (I), ##STR1## wherein: n represents the integer 1 or 2;
REFERENCES:
patent: 2922816 (1960-01-01), Bruce
patent: 3972925 (1976-08-01), Souter
patent: 3985723 (1976-10-01), Panetta
patent: 4399276 (1983-08-01), Miyasakawa
patent: 4473692 (1984-09-01), Miyasakawa
patent: 4545880 (1985-10-01), Miyasakawa
patent: 4778891 (1988-10-01), Tagawa et al.
patent: 4894456 (1990-01-01), Wall
patent: 4943579 (1990-07-01), Vishnuvajjala
patent: 4981968 (1991-01-01), Wall et al.
patent: 5049668 (1991-09-01), Wall et al.
patent: 5053512 (1991-10-01), Wani et al .
Kingsbury, et al., J. Med. Chem., 34, 98 (1991).
Lui, F., CRC Critical Review in Biochem., 1-24, 15 (1983).
Vosberg, H., Current Topics in Microbio. and Immu., 19, Springer-Verlag, Berlin, (1985).
Giovanella, et al., Science, 246, 1046 (1989).
Wani et al., J. Med. Chem., 30, 2317-2319 (1987).
Wani et al., J. Med. Chem., 29, 235-63 (1986).
March, Advanced Organic Chem., 3rd Ed, p. 179, John Wiley & Sons, NY (1925).
Lehninger, A., Principles of Biochem., 813, Worth Publishers, NY (1982).
Wani et al., J. Med. Chem., 23, 554-560 (1980).
Sugasawa, et al., J. Org. Chem., 44, No. 4, 578 (1979).
Wall and Wani, Ann. Rev. Pharmacol, Toxical, 17, 117 (1977).
Abbott, Cancer Treatment Reports, 60, No. 8, 1007 (1976).
Schultz, Chem. Rev., 73, No. 4, 385 (1973).
Wani et al., J. Am. Chem. Soc., 99, 3631 (1972).
Muggia, et al., Canc. Chemo. Reports, 56, No. 56, No. 4, 515 (1972).
Gottlieb et al., Canc. Chemo. Reports, 54, No. 6, (1970).
Jaxel, et al., Cancer Research, 49, 1465 (1989).
Giovanella, et al., Cancer, 52, 1146 (1983).
Boven, et la., The Nude Mouse in Oncology Research, CRC Press, Boca Raton, Fla. (1991).
Fiebig, Human Tumor Xenographs in Anticancer Drug Dev., "Comparison of Tumor Response in Nude Mice and in Patients," Winograd, et al., Eds. ESO Monographs, Springer, Heidelberg, 25 (1988).
Lackey Karen
Sternbach Daniel D.
Daus Donald G.
Glaxo Inc.
Joyner Charles T.
LandOfFree
Preparation of water soluble camptothecin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation of water soluble camptothecin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of water soluble camptothecin derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-30753