Preparation of virus sub-unit vaccines

Details Preparation of virus sub-unit vaccines Preparation of virus sub-unit vaccines

1978-02-21

1979-06-12

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

195 14, 195 15, A61K 3912, A61K 3918

Patent

active

041580540

ABSTRACT:
Virus sub-unit vaccines which are substantially free from pyrogens, virion nucleic acids and unwanted antigenic material are prepared by introducing inactivated whole virus into a continuous loading zonal ultracentrifuge provided with a density gradient containing a haemolytic surfactant and binding the split sub-units isopycnically. All ether-sensitive viruses can be used, especially influenza virus.

REFERENCES:
patent: 3149036 (1964-09-01), Woodhoor et al.
patent: 3519400 (1970-07-01), Anderson
patent: 3847737 (1974-11-01), Kanarak
Corbel et al., J. Hyg. 68:77-80, 81-95 (1970) Degradation of Influenza Virus by Non-Ionic Detergent, Soluble Antigens Obtained From Influenza Virus by Treatment with Non-Ionic Detergent.
Cline et al., Nature 212:487-489 (1966) Improved Continuous Flow Centrifugation With Banding.
Anderson et al. C.A.72 #28717z 28618a #63431y, (1970), C.A. 66 #8701s (1967).
Anderson et al., Analytical Biochemistry 32:460-494; 495-511 (1969).
Reimer et al., Science 152:1379-1381, Jun. 3, 1966, Influenza Virus Purification with the Zonal Ultra-Centrifuge.
Reimer et al., J. Bact. 92:1271-1272, Oct. 1966, Comparison of Techniques for Influneza Virus Purification.
Reimer et al., J. Virol., vol. 1, No. 6:1207-1216, Dec. 1967, Purification of Large Quantities of Influenza Virus by Density Gradient Contrifugation.

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