Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1990-01-29
1992-10-27
Stone, Jacqueline
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
424 858, 424530, 435236, 514 2, C07K 1506, C12N 900, A61K 3514, A61K 39395
Patent
active
051590646
ABSTRACT:
Antibodies, including monoclonal antibodies (Mabs), can be made substantially free of infectious viruses by storing them in a liquid state at conditions of pH, temperature and time sufficient to inactive substantially all infectious viruses. Preferred inactivation methods involve use of a pH equal to or less than about 4.0 at a temperature of at least about 5.degree. C. for at least about 16 hours.
REFERENCES:
patent: 2897123 (1959-07-01), Singher
patent: 4396608 (1983-08-01), Tenold
patent: 4440679 (1984-04-01), Fernandes et al.
patent: 4640834 (1987-02-01), Eibl et al.
patent: 4762714 (1988-08-01), Mitra et al.
patent: 4948877 (1990-08-01), Mitra et al.
Mitra Gautam
Mozen Milton M.
Giblin James A.
Miles Inc.
Stone Jacqueline
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