Preparation of tris(hydroxymethyl)aminomethane

Details Preparation of tris(hydroxymethyl)aminomethane Preparation of tris(hydroxymethyl)aminomethane

1979-01-25

1980-11-11

Doll, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

568712, C07C 8511

Patent

active

042332451

ABSTRACT:
Tris(hydroxymethyl)aminomethane, an intermediate of organic synthesis, in ystalline form is made by formylation followed by hydrogenation. Nitromethane and formaldehyde in a molar ratio on the order of 1:3 are reacted in a concentrated alcohol medium made up of a 2 to 5% mixture of methylene chloride in methanol, in the presence of 1 to 10 milliequivalents per mole of nitromethane of a solid base catalyst selected from sodium or potassium, with agitation for a period between 3 and 36 hours at a temperature below 50.degree. C.

REFERENCES:
patent: 2139120 (1938-12-01), Hass et al.
patent: 3564062 (1971-02-01), Tindall

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