Preparation of trifluoromethylbenzonitrile from trifluoromethylb

Details Preparation of trifluoromethylbenzonitrile from trifluoromethylb Preparation of trifluoromethylbenzonitrile from trifluoromethylb

1987-12-07

1989-02-28

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C12000

Patent

active

048087467

ABSTRACT:
In preparing trifluoromethylbenzonitrile by reaction of trifluoromethylbenzaldehyde with hydroxylamine, the rate of reaction is enhanced and formation of trifluoromethylbenzamide is suppressed by carrying out the reaction in an organic solvent which is immiscible with water and has a sufficiently high boiling point, e.g. nitrotoluene, and continuously distilling by-produced water from the reaction system. The solvent can easily and almost entirely be recovered and reused.

REFERENCES:
patent: 4211721 (1980-07-01), Cotter
patent: 4235807 (1980-11-01), Fuhlhage
patent: 4456562 (1984-06-01), Tamura et al.
Hunt, Chemistry & Industry, Nov. 1961, p. 1873.
"A Convenient One-step conversion of Aldehydes into Nitriles", by T. van Es., J. Chem Soc., (1965) p. 1564.

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