Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2005-09-20
2005-09-20
Morris, Patricia L. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S334000
Reexamination Certificate
active
06946555
ABSTRACT:
The invention provides a process for the preparation of a compound of the formula:or an acid addition or base salt thereof,whereinR is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and trifluoromethyl;R1is C1-C6alkyl; and“Het” is pyrimidinyl optionally substituted by 1 to 3 substituents each independently selected from C1-C4alkyl, C1-C4alkoxy, halo, oxo, benzyl and benzyloxy,comprising reaction of a compound of the formula: wherein R is as previously defined for a compound of the formula (I), with a compound of the formula: wherein R1and “Het” are as previously defined for a compound of the formula (I) and X is chloro, bromo or iodo, in the presence of zinc, iodine and/or a Lewis acid and an aprotic organic solvent: said process being optionally followed by conversion of the compound of the formula (I) to an acid addition or base salt thereof.
REFERENCES:
patent: 5364938 (1994-11-01), Dickinson et al.
patent: 5498612 (1996-03-01), Obata et al.
patent: 5567817 (1996-10-01), Ray et al.
patent: 357241 (1990-03-01), None
patent: 440372 (1991-08-01), None
Obata et al II, Preparatoin of Aminopyrimidine, etc CA 122: 31551 (1995).
Obata et al III, Preparation of (Aralkylamino), etc CA 121: 179607 (1994).
Fujii et al, “Preparation of 4,5. Dihalogene, etc” CA 119: 271193 (1993).
Cram and Hammond , “Organic Chemistry” McGraw-Hill Book Co., NY (1964) 2nd Ed. pp 565-67.
Dickinson, R. P., et al., Bioorganic and Medicinal Chemistry Letters, 1996, 2031-2036, vol. 6, No. 16.
George, D., et. al., Antimicrobial Agents and Chemotherapy, 1996, 86-91.
Cram and Hammond, Organic Chemistry, 1964, 565-567, McGraw-Hill Book Co., New York, 2nd Edition.
R. P. Dickinson et al., Bioorganic & Medicinal Chemistry Letters, vol. 6, No. 16, pp. 2031-2036 (1996).
D. George et al., Antimicrobial Agents and Chemotherapy, pp. 86-91 ( Jan. 1996).
Butters Michael
Pettman Alan John
Djuardi Elsa
Morris Patricia L.
Pfizer Inc
Richardson Peter C.
Zielinski Bryan C.
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