Preparation of transition metal imine complexes

Details Preparation of transition metal imine complexes Preparation of transition metal imine complexes

2001-02-07

2001-10-30

Wu, David W. (Department: 1713)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Polymers from only ethylenic monomers or processes of...

C502S150000, C502S167000, C502S169000

Reexamination Certificate

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06310153

ABSTRACT:

FIELD OF THE INVENTION
Preparation of imine complexes of certain transition metals from selected metal compounds and organic compounds which are precursors of imines in essentially a single step are described. The imine complexes are useful in the polymerization of olefins, and may be used directly without isolation.
TECHNICAL BACKGROUND
Imine complexes of certain transition metals such as iron, palladium, cobalt, nickel and others are important parts of catalyst systems for the polymerization of olefins, see for instance U.S. Pat. No. 5,714,556, World Patent Applications 96/23010, 97/48737, 97/48735, 97/38024, and U.S. patent application Ser. No. 08/991372, filed Dec. 16, 1997 (now U.S. Pat. No. 5,955,555) all of which are hereby included by reference. These and other references generally describe the synthesis of these types of imine complexes as the reaction of the imine containing ligand with various types of transition metal compounds to form the transition metal imine complex. These methods usually involve the use of substantially anhydrous conditions to avoid hydrolysis of the starting transition metal compound and/or any intermediates or the desired final complex.
For the most part, the imines themselves are not commercially available, usually being made from the corresponding carbonyl compound, such as a ketone or aldehyde, and an amine, often an aromatic amine. When made by this method, water is a by-product. Since this imine forming reaction is usually considered to be an equilibrium, to drive the reaction to completion the water is often removed during the synthesis of the imine, for example by distillation, preferably azeotropic distillation, or by formation of a hydrate, preferably an inorganic hydrate.
Thus imine complexes of transition metals are often made in two step processes, imine synthesis, and then synthesis of the metal complex. A simpler, especially one step, synthesis would be preferable if they used the same starting materials since they would usually be cheaper than a two step synthesis.
Many complexes of imines and transition metals have been synthesized and reported in the literature. In addition to the above references, see for instance: H. tom Dieck et al., Inorg. Chim. Acta, vol. 177, p. 191-197 (1990); R. van Asselt, et al., J. Am. Chem. Soc., vol. 116, p. 977-985 (1994); H. tom Dieck, et al., Z. Naturforsch. B, vol. 33, p. 1381 et seq. (1978); H. G. von Schnering, et al., Chem. Ber., vol. 109, p. 1665 et seq. (1976); and H. tom Dieck et al., Chem. Ber., vol. 109, p. 1657 et seq. (1976).
R. van Asselt, et al., Recl. Trav. Chim. Pays-Bas., vol. 113, p. 88-98 (1994) describes the synthesis of certain zinc and nickel (x-diimine complexes from the diketone and aromatic amine. In many of the syntheses, (glacial) acetic acid is present.
SUMMARY OF THE INVENTION
This invention concerns a process for the production of a transition metal complex of an imine, comprising, contacting under imine forming conditions in an aprotic solvent, a transition metal compound, a first organic compound containing at least one aldehyde or ketone group, and a second organic compound which is a primary amine to form said transition metal complex of said imine, and provided that said transition metal is nickel, palladium, iron and cobalt.
DETAILS OF THE INVENTION
It is well known that imines can be made by the reaction of a carbonyl group such as a ketone or aldehyde with a primary amine, the reaction being:
Since (1) is generally thought of as being an equilibrium reaction, it is usually driven to completion (formation of the imine) by removing the by product water that is formed. This can be done in a variety of ways, for instance removing the water by azeotropic distillation or as a hydrate of an inorganic salt. In order to efficiently utilize carbonyl compound and amine-used in (1), they should preferably be present in the reaction in approximately the same ratio as they are in the product.
It has surprisingly been found that imine complexes [the imine(s) in the complex may contain one or more imine groups] of certain transition metals can be made in an aprotic solvent by addition of salts of those metals to a process in which reaction (1) is being carried out, even though water is generated as a by product. Thus reaction (1) is carried out in the presence of a suitable salt of the desired transition metal. The ratio of transition metal salt to the other ingredients is not critical, but in order to efficiently utilize all of the ingredients the ratio of moles transition metal compound to moles of the other reactants is such that they are approximately the same as they are in final desired imine complex. The transition metal compound is preferably present at the beginning of the process, but may be added at any time during the formation of the imine.
Useful transition metal compounds include metal halides, especially chlorides and bromides, and carboxylates. Zerovalent metal compounds that are not too sensitive to water may be used in conjunction with a suitable oxidizing agent (which are known in the art). Preferred transition metal compounds are halides, especially chlorides and bromides.
Any transition metal may be used. Transition metals are those metals in Groups 3-12 (IUPAC notation), and metals in Groups 3-11 are preferred and metals in Groups 8-10 are especially preferred. Specific preferred transition metals are nickel, cobalt, iron and palladium, and nickel is especially preferred.
Process conditions for forming imines are well known and will be found in the various references cited in the Technical Background section, and also in R. L. Reeves in S. Patai, Ed., The Chemistry of the Carbonyl Group, Interscience Publishers, London, 1966, p. 608-619, and J. K. Whitesell in B. M. Trost, et al., Ed., Comprehensive Organic Synthesis, Vol. 6, Pergamon Press, Oxford, 1991, p. 719, which are both hereby included by reference.
The present process is preferably performed at a temperature of about 0° C. to about 250° C., more preferably about 20° C. to about 130° C. While pressure is not critical, and the process will probably be most often be carried out at ambient pressure, higher or lower pressures (than atmospheric pressure) may be used, for example to control the process temperature while distilling off by-product water.
Preferred primary amines in the process are aryl amines, i.e., R
1
is an aryl or substituted aryl group. Aryl herein includes groups that have one or more aromatic rings which may be fused, as in naphthyl, or connected by a covalent bond, as in 2-phenylphenol (o-biphenylyl). It is preferred that the aromatic rings of the aryl group are carbocyclic rings, and it is more preferred that R
1
is phenyl or substituted phenyl. Useful substitutents on a substituted phenyl group are alkyl, especially alkyl containing 1 to 4 carbon atoms, halo, especially chloro, phenyl, and halo substituted alkyl, especially fluoro substituted alkyl. It is also preferred that the phenyl group be substituted in the 2, or 2 and 6, positions.
The reaction is conducted in an aprotic solvent. By aprotic is meant the solvent has no protons whose pKa is about 20 or more, more-preferably about 25 or more. Useful solvents include aromatic hydrocarbons such as benzene and toluene, xylene, chlorobenzene and o-dichlorobenzene. Since the transition metal complex may often be used in conjunction with other types of compounds (such as alkyl aluminum compounds) as a catalyst system for the polymerization of olefin, the absence of protic solvents is an advantage, since the solvent need not be removed before adding an alkyl aluminum compound.
The carbonyl compound may contain more than one carbonyl group which may form an imine. Useful carbonyl compounds include &agr;,&bgr;-diones, 2,6-pyridinedicarboxyaldehydes, 2,6-diacylpyridines, cyclic &agr;,&bgr;-diones, 1,3-diones and ketoaldehydes. Specific useful carbonyl compounds include glyoxal, 2,3-butanedione, acenapthenequinone, 2,6-diacetylpyridine, 2,6-pyridinedicarboxaldehyde, 1,2-cyclohexanedione, and pyruvaldehyde.
The transi

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