Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols

Details Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols

1989-01-23

1990-11-27

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

549551, 549554, 549563, 564133, 564138, 564143, C07C23102

Patent

active

049737503

ABSTRACT:
A novel sequence of highly selective chemical reactions for conversion of 3-Aryl-2-propyn-1-ols into cis-1-Aryl-3-fluoro-1-propene and into D,L-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanols is disclosed. Preparation of D-(threo)-1-Aryl-2-acylamido-3-fluoro-1-propanol antibacterial agents including the D-(threo)-3-fluoro-3-deoxy derivatives of chloramphenicol and thiamphenicol is also disclosed.

REFERENCES:
patent: 4235892 (1980-11-01), Nagabhushan
patent: 4311857 (1982-01-01), Nagabhushan
patent: 4361557 (1982-11-01), Nagabhushan
patent: 4458084 (1984-07-01), Kelly
patent: 4582918 (1986-04-01), Nagabhushan et al.
patent: 4677214 (1987-06-01), Nagabhushan et al.
Coll et al., "Bicyclo [3.3.3] Undecane and 1-Azabicyclo," etc. J.A.C.S. 94, pp. 7092-7099 (1972).

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