Preparation of therapeutic agents

Details Preparation of therapeutic agents Preparation of therapeutic agents

1978-09-25

1980-06-24

Myers, Jane S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

260315, 2603261, 2603262, 26032647, 260335, 26034622, 2603473, 260465D, 544 35, 546 89, 549 72, 549 79, 562402, 548180, 548217, C07B 1900, C07B 2000

Patent

active

042096383

ABSTRACT:
Disclosed is a process for increasing the proportion of a desired enantiomer of a 2-arylpropionic acid which comprises heating at a temperature of at least 80.degree. C. a mixture comprising an inert liquid organic diluent and a salt of the 2-arylpropionic acid with an enantiomer of a chiral organic nitrogenous base, the base and the diluent being such that the salt of the racemic acid has a solubility of 0.1 to 10% w/v in the diluent at the operating temperature and in which process a proportion of the salt is undissolved in the diluent, whereby a proportion of one optical isomer of the acid component of the salt is converted into its enantiomer, and collecting the salt of which the acid component has an increased proportion of that enantiomer.

REFERENCES:
patent: 3600437 (1971-08-01), Marshall
patent: 3683015 (1972-08-01), Dyson
patent: 3686183 (1972-08-01), Dyson
patent: 3957861 (1976-05-01), Herr et al.
Eliel, Stereochemistry of Carbon Compounds, pp. 46-53, (1962).

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