Preparation of the high-melting polymorph of terfenadine

Details Preparation of the high-melting polymorph of terfenadine Preparation of the high-melting polymorph of terfenadine

1991-02-12

1993-09-21

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21122

Patent

active

052470920

ABSTRACT:
A process for preparing the high-melting polymorph of terfenadine, characterized by dissolving terfenadine in a water-miscible polar solvent by heating to a temperature of between 40.degree. and 100.degree. C. The solution is then percolated into a sufficient quantity of water, kept stirring at ambient temperature, to cause substantial precipitation of the high-melting terfenadine polymorph.

REFERENCES:
patent: 4742175 (1988-05-01), Fawcett et al.

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