Preparation of tetrahydrofolic acid from folic acid

Details Preparation of tetrahydrofolic acid from folic acid Preparation of tetrahydrofolic acid from folic acid

1978-11-07

1980-06-03

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D47504

Patent

active

042063078

ABSTRACT:
Improved methods for the preparation and purification of citrovorum factor are disclosed. The method includes improved procedures for hydrogenation of 10-formylfolic acid as well as for the reduction of folic acid. Also disclosed are improved procedures for opening of the imidazoline ring, and a non-chromatographic method for the purification of crude samples of citrovorum factor.

REFERENCES:
patent: 2741608 (1956-04-01), Shive

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