Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants
Patent
1989-06-23
1991-10-22
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Biocides; animal or insect repellents or attractants
424418, 424450, 435 4, 264 43, A01N 2526, A01N 2528, A61K 3722, B32B 516
Patent
active
050594214
ABSTRACT:
The present invention relates to a general method for producing sized protein-liposome conjugates exhibiting enhanced blood circulation times. The present invention also relates to the sized protein-liposome conjugate compositions produced by the method of the present invention. The protein-liposome conjugates of the present invention preferably range in size from about 75 nm to about 200 nm.
The liposomes of the invention may have a transmembrane potential across their membranes, and may be dehydrated. In addition, the composition may contain ionizable bioactive agents such as antineplastic agents, and may be used in diagnostic assays.
REFERENCES:
patent: 4193983 (1980-03-01), Ullman et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4308166 (1981-12-01), Marchetti et al.
patent: 4522803 (1985-06-01), Lenk et al.
patent: 4588578 (1986-05-01), Fountain et al.
patent: 4610868 (1986-09-01), Fountain et al.
patent: 4721612 (1988-01-01), Janoff et al.
patent: 4789633 (1988-12-01), Huang et al.
patent: 4830858 (1989-05-01), Payne et al.
patent: 4863740 (1989-09-01), Kissel et al.
patent: 4873088 (1989-10-01), Mayhew et al.
patent: 4877561 (1989-10-01), Iga et al.
patent: 4880635 (1989-11-01), Janoff et al.
patent: 4885172 (1989-12-01), Bally et al.
Rahman et al., J. Cell. Biol., 83, p. 268a, 1979.
Cullis et al. U.S. patent application No. 622,690, filed 6/20/1984.
Bally et al. U.S. patent application No. 941,913, filed 12/15/86.
Bally et al. U.S. patent application No. 749,161, filed 6/26/85.
Janoff et al. U.S. patent application No. 759,419, file 7/26/85.
Leak et al. U.S. patent application No. 476,496, filed 3/24/83.
Fountain et al. U.S. patent application No. 521,176, filed 8/8/83.
Fountain U.S. patent application No. 591,576, filed 3/20/84.
Janoff et al. U.S. patent application No. 599,691, filed 4/12/84.
Bally et al. U.S. patent application No. 811,037, filed 12/18/85.
Cullis et al. U.S. patent application No. 353,497, filed 5/15/89.
Allison et al., "Liposomes as Immunological Adjuvants," 1974, Nature, 252, p. 252.
Bangham et al., "Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids," 1965, J. Mol. Biol. 13:238-252.
Brederhorst R. et al., "Effect of Covalent Attachment of Immunoglobulin Fragments on Liposomal Integrity," Biochem., 1986, 25:5693-5698.
Carlsson et al., "Protein Thiolation and Reversible Protein-Protein Conjugation" 1978, Biochem. J., 173:723-737.
Deamer et al., "Liposome Preparation: Methods and Mechanisms," 1983, Chaper 1, pp. 27-51.
Fiske et al., "The Colorimetric Determination of Phosphorus", 1925, J. Bio. Chem., vol. 66, No. 2:375-400.
Forssen et al., "Improved Therpeutic Benefits of Doxorubicin by Entrapment in Anionic Liposomes," 1983, Cancer Res., 43:546-550.
Gabizon et al., "Liposomes as in Vivo Carriers of Adriamycin:Reduced Cardiac Uptake and Preservced Antitumor Activity in Mice", 1982, Cancer Res., 42:4734-4739.
Goundalkar et al., "Covalent Binding of Antibodies to Lipsomes Using a Novel Lipid Derivative," 1984, J. Pharm. Pharmacol., 36:465-466.
Gregoriadis, "Targeting of Drugs with Molecules, Cells and Liposomes," 1983, Trends Pharmacol Sci., 4:304-307.
Heath et al., "Antibody-Targeting Liposomes: Increase in Specific Toxicity of Methotrexate-Y-Aspartate," 1983, Proc. Acad. Sci. USA, 80:1377-1381.
Heath et al., "Covalent Attachment of Immunogloublins in Liposomes Via Glycosphingolipids," 1981, Biochim. Biophys. Acta., 640:66-81.
Heath et al., "Covalent Attachment of Horseradish Peroxidase to the Outer Surface of Liposomes," 1980, Biochium. Biophys. Acta. 599:42-62.
Ho et al., "Interactions of Antigen-Sensitized Liposomes with Immobilized Antibody: A Homogeneous Solid-Phase Immunoliposome Assay," 1985, J. Immunol., vol. 134:4035-4040.
Hope et al., "Production of Large Unilamellar Vesicles by a Rapid Extrusion Procedure. Characterization of Size Distribution, Trapped Volume and Ability to Maintain a Membrane Potential", 1981, Biochim. Biophys. Acta., 812:55-65.
Huang L., "Liposome-Cell Interactions in Vitro", 1983, Liposomes, Ed. Marc J. Ostro by Marcel Dekker, New York, pp. 87-124.
Huang et al., "Characterization on Antibody Covalently Coupled to Liposomes," 1982, Biochim. Biophys. Acta., 716:140-150.
Huang et al., "Interactions of Immunoliposomes with Target Cells," 1983, J. Biol. Chem., 258, No. 22:14034-14040.
Hunt, A. C., "Liposomes Disposition In Vivo, V. Liposome Stability in Plasma and Implications for Drug Carrier Function," 1982, Biochim. Biophys. Acta., 719:450-463.
Ishimori et al., "Liposome Immune Lysis Assay (LILA): A Simple Method to Measure Anti-Protein Antibody Using Protein Antigen-Bearing Liposome," 1984, J. Immunol. Methods, 75:351-360.
Leserman et al., "Targeting to Cells of Fluorescent Liposomes Covalently Coupled with Monoclonal Antibody or Protein A," 1980, Nature, 288:602-604.
Leserman et al., "Covalent Coupling of Monoclonal Antibodies and Protein A to Liposomes: Specific Interaction with Cells in Vitro and in Vivo," Liposome Technology, III, 1984, CRC Press, Inc., CA., pp. 29-40.
Loughery et al., "A Non-Covalent Method of Attaching Antibodies to Liposomes," 1987, Biochim. Biophys. Acta., 901:157-160.
Martin et al., "Irreversible Coupling of Immunoglobulin Fragments to Preformed Vesicles," 1982, J. Biol. Chem., 257, pp. 286-288.
Martin et al., "Immunospecific Targeting of Liposomes to Cells: A Novel and Efficient Method for Covalent Attachment of Fab' Fragments via Disulfide Bonds," 1981, Biochemistry, 20:4229-4238.
Papahadjapoulos et al., "Phospholipid Model Membranes I. Structural Characteristics of Hydrated Liquid Crystals," 1967, Biochim. Biophys. Acta, 135:624-638.
Papahadjopoulos et al., "Targeting of Liposomes to Tumor Cells in Vivo," 1988, Annals of the N.Y. Academy of Sci., ed. R. L. Juliano, 507, 64-74.
Rahman et al., "In Vivo Cell Targeting by Liposomes Containing Glycolipids," 1979, J. Cell. Biol., MF1509.
Rahman et al., "Doxorubicin-Induced Chronic Cardiotoxicity and Its Protection by Liposomal Administration," 1982, Cancer Res. 42:1817-1825.
Sato et al., "Effects of Dose and Vesicle Size on the Pharmacokinetics of Liposomes," 1986, Chem. Pharm. Bull., 34:4244-4252.
Sharkey et al., "Targeting of Antibody Coated Liposomes to Tumor Cells Producing Carcinoembryonic Antigen", 1979, Fed. Proc., 38, 1089, #4557.
Stein et al., "Biological Stability of [.sup.3 H] Cholesteryl Oleyl Ether in Cultured Firbroblasts and Intact Rat," 1980, Febs Lett., vol. 111: 104-106.
Urdal et al., J. Biol. Chem., "Tumor-Associated Ganglio-N-Triosylceramide", 1984, J. Biol. Chem., 255:10509-10516.
Wolff et al., "The Use of Monoclonal Anti-Thy, IgG,.sub.1 " for the Targeting of Liposomes to AKR-A Cells In Vitro aned In Vivo, 1984, Biochim Biophys. Acta., 802:259-273.
Bally Marcel B.
Choi Lewis S. L.
Cullis Pieter R.
Loughrey Helen C.
Wong Kim F.
Bloom Allen
Griffin Ronald W.
Kurtz Catherine
The Liposome Company Inc.
LandOfFree
Preparation of targeted liposome systems of a defined size distr does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation of targeted liposome systems of a defined size distr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of targeted liposome systems of a defined size distr will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-107137