Preparation of T-cell and T-cell membrane for use in prevention

Details Preparation of T-cell and T-cell membrane for use in prevention Preparation of T-cell and T-cell membrane for use in prevention

1989-03-15

1992-05-19

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Blood

514455, 514825, 514866, 514885, 514903, A61K 3135, A61K 3514

Patent

active

051147211

ABSTRACT:
Pharmaceutical preparations are provided for preventing or treating autoimmune diseases in which the active principle is activated T-lymphocyte cells, specific for the autoimmune disease to be treated, which cells have been treated by incubation with a photoactivatable psoralen cross-linking agent, such as 8-methoxypsoralen, and then photoactivated. The active principle may also be the membrane fraction of such cells. Such preparations may be formulated into pharmaceutical compositions and administered to prevent or treat autoimmune disesases.

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Lischka et al., CA 89:100269a.
Roberts et al., CA 91:69662p.
Yurkow et al., J. Bio. Chem., 262(18), pp. 8439-8442 (1987).
Bohnert et al., CA 88:3899c.
Edelson et al., N. Engl. J. Med., 316, pp. 297-303 (1987).
Laskin et al., Proc. Natl. Acad. Sci. USA, 82, pp. 6158-6162 (1985).
Lider et al., Proc. Natl. Acad. Sci. USA, 84, pp. 4577-4580 (1987).
Ben-Nun et al., J. Immunol., 129(1) pp. 303-308 (1982).

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