Preparation of sulfonic acid esters

Details Preparation of sulfonic acid esters Preparation of sulfonic acid esters

1990-06-26

1991-11-19

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

558 52, C07D22316

Patent

active

050668013

ABSTRACT:
The invention relates to novel sulfonic acid esters of formula I ##STR1## wherein R.sup.1 is C.sub.5 -C.sub.6 cycloalkyl which is unsubstituted or substituted by C.sub.1 -C.sub.7 alkyl, unsubstituted or substituted phenyl, R.sup.2 is C.sub.1 -C.sub.7 alkyl, R.sup.3 is phenyl which is substituted by halogen or nitro, and the asterisk denotes a carbon atom that is either present in the preponderant number of molecules in the S configuration or in the preponderant number of molecules in the R configuration.
These compounds can be prepared by enantio-selective reduction of 4-R.sup.1 -substituted .alpha.-oxobutyric acid compounds and subsequent conversion of the resultant .alpha.-hydroxy group into the --OSO.sub.2 --R.sup.3 group. The compounds of formula I are suitable intermediates for the preparation of ACE inhibitors or precursors thereof.

REFERENCES:
patent: 4344949 (1982-08-01), Hoefle et al.
patent: 4410520 (1983-10-01), Watthey
patent: 4470988 (1984-09-01), Watthey
patent: 4785089 (1988-11-01), Blaser et al.

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