Preparation of sulfo-N-hydroxysuccinimide salts

Details Preparation of sulfo-N-hydroxysuccinimide salts Preparation of sulfo-N-hydroxysuccinimide salts

1997-09-18

1999-04-06

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548548, 548551, 549262, 549505, C07D207416, C07D20710, C07D30736, C07D30706

Patent

active

058920579

ABSTRACT:
The salt of a sulfonated succinic acid is cyclized, then converted to novel sulfonated hydroxamic acids by reaction with hydroxylamine (which is added or formed in situ), and the novel hydroxamic acid is then cyclized to the sulfo-N-hydroxysuccinimide salt. This synthetic procedure is simple, direct, and more rapid than present procedures for synthesis of the succinimide. Novel sulfo-hydroxamic acid intermediates are formed during this procedure.

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