Preparation of substituted guanidines

Details Preparation of substituted guanidines Preparation of substituted guanidines

1992-03-20

1994-03-29

Robinson, Allen J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

546143, 546163, 546304, 549288, 552 8, 558418, C07C27702

Patent

active

052986578

ABSTRACT:
A process for the preparation of a substituted guanidine by reacting a substituted cyanamide with ammonia or a substituted amine in the presence of a Lewis acid catalyst. Also disclosed is a process for the preparation of a tri-substituted guanidine by reacting a mono-substituted cyanamide with a di-substituted amine.

REFERENCES:
patent: 4051256 (1977-09-01), Swallow
patent: 4709094 (1987-11-01), Weber et al.
Geluk et al. "Synthesis and Antiviral Properties of 1-Adamantylguanidine. A Modified Method for Preparing t-Alkylguanidines", Journal of Medical Chemistry 12:711-715, 1969.
Safir et al. "Experimental Chemotherapy of Trypanosomiasis. II. The Preparation of Compounds Related to p-Phenylenediaguanidine", Journal of Organic Chemistry 924-932, 1948.
Oxley et al. "Amidines. Part VII. Preparation of Amidines from Cyanides, Aluminium Chloride, and Ammonia or Amines", Journal of Chemical Society 1110-1116, 1947.
Cooper et al. "N-Phenylbenzamidine" Organic Synthesis, Coll. vol. IV, 769-771 (1955).

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